ArticleCNS neuroscience & therapeutics2025
Diagnosis and Subtyping of Autoimmune Encephalitis Using an Attention-Based Multi-Instance Learning Model: A Multi-Center
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Diagnosis and Subtyping of Autoimmune Encephalitis Using an Attention-Based Multi-Instance Learning Model: A Multi-CenterCNS neuroscience & therapeutics · 2025Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundThe aim was to develop an attention-based model using
methodsThis multi-center retrospective study enrolled 390 participants: 222 definite AE patients (comprising four subtypes: LGI1-AE, NMDAR-AE, GABAB-AE, GAD65-AE), 122 age- and sex-matched healthy controls, and 33 age- and sex-matched antibody-negative AE patients along with 13 age- and sex-matched viral encephalitis patients, both serving as disease controls. An attention-based multi-instance learning (MIL) model was trained using data from one hospital and underwent external validation with data from other institutions. Additionally, a multi-modal MIL (m-MIL) model integrating imaging features, age, and sex parameters was evaluated alongside logistic regression (LR) and random forest (RF) models for comparative analysis.
resultsThe attention-based m-MIL model outperformed classical algorithms (LR, RF) and single-modal MIL in AE vs. all controls binary classification, achieving the highest accuracy (84.00% internal, 67.38% external) and sensitivity (90.91% internal, 71.19% external). For multiclass AE subtype classification, the MIL-based model achieved 95.05% (internal) and 77.97% (external) accuracy. Heatmap analysis revealed that NMDAR-AE involved broader brain regions, including the medial temporal lobe (MTL) and basal ganglia (BG), whereas LGI1-AE and GABAB-AE showed focal attention on the MTL and BG. In contrast, GAD65-AE demonstrated concentrated attention exclusively in the MTL.
conclusionThe m-MIL model effectively discriminates AE patients from controls and enables subtyping of different AE subtypes, offering a valuable diagnostic tool for the clinical assessment and classification of AE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.