Evidence map›Paper›PMID 40755247›Full record

ArticleGut microbes2025

Role of the gut microbiome in frequent gut colonization with extended-spectrum β lactamase-producing Enterobacterales among Peruvian children.

Maya L Nadimpalli, Neha Sehgal, Luismarcelo Rojas-Salvatierra, Robert H Gilman, Ashlee M Earl, Colin J Worby, Madison Schwab, Amy J Pickering, Monica J Pajuelo

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Maya L NadimpalliGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0000-0002-6526-116X
Neha SehgalGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0009-0000-0930-8560
Luismarcelo Rojas-SalvatierraLaboratorio de Microbiología Molecular, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID 0000-0003-2892-7871
Robert H GilmanLaboratorio de Microbiología Molecular, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID 0000-0002-9037-0712
Ashlee M EarlInfectious Disease and Microbiome Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-7857-9145
Colin J WorbyInfectious Disease and Microbiome Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-9132-7249
Madison SchwabProgram in Population Biology, Ecology, and Evolution, Emory University, Atlanta, GA, USA.ORCID 0000-0003-0748-1858
Amy J PickeringDepartment of Civil and Environmental Engineering, University of California, Berkeley, CA, USA.ORCID 0000-0001-6193-2221
Monica J PajueloLaboratorio de Microbiología Molecular, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID 0000-0003-3662-2250

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI EARL, ASHLEE MIRIAM · 2014 to 2024
$66.5M
Graduate and Postdoctoral Training in ToxicologyT32ES012870 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2004 to 2026
$9.1M
CTSA Institutional Mentored Career Development Program (KL2)KL2TR002545 · NCATS · TUFTS UNIVERSITY BOSTON · PI FREUND, KAREN · 2018 to 2022
$5.0M
Natural infection of norovirus and sapovirus in a birth cohort in a Peruvian periurban communityR01AI108695 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CHAKRABORTY, SUBHRA, GILMAN, ROBERT H · 2015 to 2019
$5.0M
NCATS NIH HHS KL2 TR002545NIAID NIH HHS R01 AI108695NIAID NIH HHS U19 AI110818NIEHS NIH HHS T32 ES012870
6 · The paper itself

Abstract

Gut colonization with extended-spectrum beta lactamase-producing Enterobacterales (ESBL-E) is increasingly common among children in low- and middle-income countries. Some children nevertheless remain never or rarely colonized during early life. Understanding how this protection is conferred could be helpful for designing future interventions to protect children's health. Here, we investigated whether differences in gut microbiome development could underlie differential susceptibility to ESBL-E gut colonization over time among children in peri-urban Lima. Weekly stool and daily surveys were collected from 345 children < 3 years old during a 2016-19 study of enteric infections. A subset of children (

Indexed as

beta-LactamasesEnterobacteriaceaeEnterobacteriaceae InfectionsGastrointestinal MicrobiomeChild, PreschoolFecesFemaleHumansInfantMaleMetagenomicsPerubeta-LactamasesAMRchildren’s healthESBLLMICMetagenomic sequencingmicrobiome

Identifiers

PMID40755247
PMCPMC12323407

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.