ArticleACS nano2025
Hybrid Cell Membrane-Functionalized Nanoagents Synergistically Enhance Cuproptosis-Mediated Immunotherapy by Dual Modulation of Glycolytic Metabolism and Tumor Microenvironments.
Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Cuproptosis and ferroptosis: signal pathways, diseases and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Copper homeostasis and cuproptosis: molecular mechanisms and therapeutic opportunities.Molecular biomedicine · 2026Review
- Biomimetic Cell Membrane-Based Drug Delivery Systems for Oral Diseases: Engineering Strategies, Targeting Mechanisms, and Translational Challenges.Pharmaceutics · 2026Review
- Metal-dependent regulated cell death: Molecular architecture and translational frontiers.iMeta · 2026Review
- Harnessing Cuproptosis resistance to advance cancer therapeutics.Apoptosis : an international journal on programmed cell death · 2026Review
- Tumor-homing cerium nanozyme platform enables coordinated drug release and STING activation for bladder cancer treatment.Journal of nanobiotechnology · 2026Article
- Glycolysis-related gene signatures in spinal cord injury pathophysiology identification through integrative gene expression analysis.Frontiers in genetics · 2026Article
- Targeting lung cancer: synergistic therapeutic strategy of cuproptosis and immunogenic cell death.Frontiers in cell and developmental biology · 2026Review
- Cuproptosis-triggering nanomedicine boosts antitumor immunotherapy.Theranostics · 2026Review
- Natural Macrophage Membrane-Coated Nanoparticles as a Multifaceted Sepsis Therapeutic to Sequester Inflammatory and Toxic Mediators.ACS nano · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
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Abstract
Glycolytic activity of cancer cells not only reduces their vulnerability to cuproptosis but also heightens the immunosuppressive state of the tumor microenvironment (TME). Our study introduces a nanoplatform called dual-remodeling cuproptosis-inducing agent with hybrid cell membrane coating (DREAM), which is crafted to simultaneously modify the metabolic and immunological landscapes of the TME to enhance cuproptosis-driven immunotherapy. This platform exploits cancer-cell-derived membranes for homologous targeting, enhancing tumor specificity, intratumoral penetration, and intracellular copper delivery. DREAM's disruption of glycolysis intensifies the copper overload, triggering cuproptosis in cancer cells. Additionally, it alleviates immunosuppression and bolsters immune responses facilitated by the immunogenic cell death from cuproptosis, further potentiated by the immunostimulatory effect of M1 macrophage membranes. The outcome is a pronounced efficacy in curbing tumor growth and distant metastasis in squamous cell carcinoma and also in suppressing melanoma proliferation and lung metastasis. This research underscores the vital interaction among inhibiting glycolysis, enhancing sensitivity to cuproptosis, and activating immune responses, thereby paving a feasible and integrated pathway in cancer immunotherapy.
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