Evidence map›Paper›PMID 40755182›Full record

ArticleAmerican journal of industrial medicine2025

Biomarkers of Kidney Function and Injury Across Fire Seasons and During a Mid-Season Fire Incident in the Wildland Firefighter Exposure and Health Effect (WFFEHE) Study.

Lynne E Pinkerton, Sara E Luckhaupt, Stephen Bertke, Corey R Butler, Thomas R Hales, Kathleen M DuBose, Alejandra Ramirez-Cardenas, Deborah Sammons, Christine Toennis, Molly R West and 1 more

Abstract read
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Article in American journal of industrial medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lynne E PinkertonMaximus Inc., McLean, Virginia, USA.ORCID 0000-0002-8669-487X
Sara E LuckhauptCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Field Studies and Engineering, Cincinnati, Ohio, USA.ORCID 0000-0002-3000-8818
Stephen BertkeCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Field Studies and Engineering, Cincinnati, Ohio, USA.ORCID 0000-0002-3047-3816
Corey R ButlerCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Western States Division, Denver, Colorado, USA.
Thomas R HalesCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Denver, Colorado, USA.
Kathleen M DuBoseCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Western States Division, Denver, Colorado, USA.
Alejandra Ramirez-CardenasCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Western States Division, Denver, Colorado, USA.
Deborah SammonsCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Science Integration, Cincinnati, Ohio, USA.
Christine ToennisCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Cincinnati, Ohio, USA.
Molly R WestUnited States Forest Service, National Technology and Development Program, Missoula, Montana, USA.
Christa R HaleCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Western States Division, Denver, Colorado, USA.ORCID 0000-0003-2496-0527

Funding

Funding for the WFFEHE study was provided by the National Institute for Occupational Safety and Health and the National Wildfire Coordinating Group.Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundOccupational heat stress among wildland firefighters (WFFs) performing arduous work or working in hot work environments may cause kidney dysfunction and injury.

methodsKidney function and injury biomarkers (serum and urine) were measured among 39 WFFs pre- and post-fire season in 2018-2019. The same biomarkers were measured in 19 of these 39 WFFs over 3 days during a 2019 mid-season fire incident. Median differences in biomarker concentrations across the fire season and across the mid-season incident were evaluated using the Sign test. The primary outcome of interest was the cystatin C-based estimated glomerular filtration rate (eGFR

resultsThe eGFR

conclusionsA temporary decrease in kidney function and changes in biomarkers of kidney injury were observed during a wildland fire incident. Additional research is warranted to confirm these findings, assess associations with occupational heat stress, and determine whether persistent, clinically relevant kidney injury and dysfunction occur among WFFs over time. The findings also support the need for continued efforts to promote optimal hydration of WFFs.

Indexed as

FirefightersHeat Stress DisordersOccupational DiseasesOccupational ExposureWildfiresAdultBiomarkersCystatin CFemaleFiresGlomerular Filtration RateHumansLipocalin-2MaleMiddle AgedSeasonsBiomarkersCystatin CLipocalin-2firefighterskidney functionwildfirewildland

Identifiers

PMID40755182
PMCPMC12393010

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.