ArticleAngewandte Chemie (International ed. in English)2025
Electrolyte-Controlled Regiodivergent Continuous Flow Electroselenocyclisations.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Electrolyte-Guided Selectivity Unlocks Pathway Control in Electrochemical Olefin Functionalization.Journal of the American Chemical Society · 2026Article
- Silver-Mediated Electrosynthesis of Substituted Isoquinolines via Cyclization of 2‑Ethynylbenzaldehydes.ACS omega · 2025Article
- Electrolyte-Controlled Regiodivergent Continuous Flow Electroselenocyclisations.Angewandte Chemie (International ed. in English) · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
Supporting electrolytes, beyond traditionally serving as ionic conductors in electrochemistry, can influence regioselectivity in electrochemical synthesis by acting as base. We present a single-pass continuous flow electrolysis method enabling selective activation of diselenides and oximes to access seleno-substituted isoquinoline and isoindole derivatives. Mechanistic studies showed a radical pathway via iminoxyl radicals to isoindole N-oxides and an ionic mechanism leading to isoquinoline N-oxides. This process leverages N-activated neutral isoquinolinium products for diverse downstream modifications. Our findings highlight the untapped potential of supporting electrolytes in regiodivergent electrochemical transformations and provide a sustainable and scalable platform for continuous flow approaches for synthesising selenium-containing heterocycles with biological relevance.
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Registered trials
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