PD-L2 Inhibits Protective Immunity, Th2 Cell Functional Quality, and GATA-3 Expression During Filarial Nematode Infection.

Johanna A Knipper, Sharon M Campbell, Judith E Allen, Matthew D Taylor

Abstract read

In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Johanna A KnipperInstitute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK.

Sharon M CampbellInstitute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK.

Judith E AllenInstitute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-3829-066X

Matthew D TaylorInstitute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-7694-8189

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Filarial nematodes infect over 200 million people, predominantly stimulating a Type 2 immune response. Protective immunity takes decades to become effective due to dominant immune suppression that develops during infection. Using Litomosoides sigmodontis infection as a murine model of filariasis, we previously demonstrated that PD-1 co-inhibition causes Th2 cells to become intrinsically dysfunctional or hypo-responsive during infection, resulting in impaired protective immunity. Τhis study demonstrates that Th2 cell-intrinsic hypo-responsiveness is associated with a loss of GATA-3 expression by CD4

Indexed as

FilariasisFilarioideaGATA3 Transcription FactorProgrammed Cell Death 1 Ligand 2 ProteinTh2 CellsAnimalsB-LymphocytesDisease Models, AnimalMiceMice, Inbred C57BLMice, KnockoutGata3 protein, mouseGATA3 Transcription FactorPdcd1lg2 protein, mouseProgrammed Cell Death 1 Ligand 2 ProteinB cellHelminthimmune‐regulationT cellTh2

Identifiers

PMID40755147

DOI10.1002/eji.70021

PMCPMC12319375

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.