ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Multimorbidity in dementia: Current perspectives and future challenges.
Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Determining six-month prognosis among people with dementia living in care homes: a systematic review of prognostic tools.Age and ageing · 2026Pooled it
- Key factors influencing post-diagnostic support and care planning for people with dementia from South Asian backgrounds: a systematic review of qualitative studies.BMC geriatrics · 2026Pooled it
- Effectiveness of interventions for the management of multimorbidity in primary care and community settings: systematic review and meta-analysis.Family practice · 2025Pooled it
- Data-driven subtyping of Alzheimer's emergency presentations using unsupervised machine learning.IBRO neuroscience reports · 2026Article
- "Co-production is catnip to my brain. I need it and I would be in care otherwise": a call for action for researchers to safeguard the integrity of co-production in dementia research.Research involvement and engagement · 2026Article
- Clinical Group Assignment in Home Health Care for Medicare Beneficiaries With ADRD: A 2019 Pre-PDGM Simulation.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Instruments for assessing geriatric nursing competence among nursing personnel: protocol for a COSMIN-based systematic review.BMJ open · 2026Article
- Practice Environment and Job Outcomes Among Primary Care Nurse Practitioners Caring for Patients With Dementia.Journal of the American Geriatrics Society · 2026Article
- Genetic and sociodemographic factors associated with trajectories of physical and mental health multimorbidity in a South Asian cohort in the UK: A multistate modelling analysis.PLoS medicine · 2026Article
- Association of micronutrient levels with dementia risk in adults in Telangana, India: a cross-sectional study (2023-2024).The Lancet regional health. Southeast Asia · 2026Article
- Predicting All-Cause Mortality Using Two Claims-Based Measures in Medicare Beneficiaries With Dementia.Medical care research and review : MCRR · 2026Article
- Plasma proteomics reveals divergent sex-specific senescence and bone biology signatures across neurodegenerative diseases.bioRxiv : the preprint server for biology · 2026Article
- Serum vitamin B12 levels and 90-day outcomes in hospitalized patients with dementia: A cohort study.Medicine · 2026Article
- Differentiating Alzheimer's disease and vascular dementia via combined OCT and OCT‑angiography analysis.Scientific reports · 2026Article
- Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease.Annals of neurology · 2026Article
- Edentulism and risk of all-cause dementia and Alzheimer's disease: A competing risk analysis by cognitive status.Journal of Alzheimer's disease : JAD · 2026Article
- Risk Stratification for In-Hospital Mortality in Alzheimer's Disease Using Interpretable Regression and Explainable AI.Geriatrics (Basel, Switzerland) · 2026Article
- Multimorbidity research in dementia: it's time to shift to a person-centred approach.Frontiers in dementia · 2026Article
- Article
- "There doesn't seem to be the help there for people who are carers": qualitative findings from a realist evaluation of hospital-to-home transitions.Innovation in aging · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
Abstract
Multimorbidity-the co-occurrence of two or more chronic health conditions-affects > 86% of people with dementia. It is associated with cognitive and functional decline, reduced health-related quality of life, increased health-care use, and higher mortality. The relationship between multimorbidity and dementia is potentially bidirectional; conditions such as hypertension and diabetes increase the risk of developing dementia, and cognitive impairment can complicate their management. This complexity presents challenges in health care and research, affecting treatment decisions and often leading to the exclusion of these individuals from clinical trials. Understanding multimorbidity through long-term prospective studies is crucial to clarify its relationship with dementia. Investigating specific disease combinations, environmental and genetic factors, and their impacts on cognitive health will guide the development of effective prediction models and inclusive intervention strategies for diverse global populations across the life course. HIGHLIGHTS: Multimorbidity affects > 86% of individuals with dementia, worsening outcomes. The relationship between multimorbidity and dementia is potentially bidirectional. Chronic conditions hinder dementia management and clinical trial inclusion. Life-course multimorbidity research is key to dementia risk reduction strategies. Prospective studies are needed to improve prediction models and interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.