Evidence map›Paper›PMID 40754938›Full record

ArticleJournal of child neurology2026

Vigabatrin Versus Adrenocorticotropic Hormone After High-Dose Prednisolone Failure for the Treatment of Epileptic Spasms.

Austin Layton, Shifteh Sattar, Jong M Rho, Jennifer H Yang, Jeffrey Gold, Michael Zimbric, Jonathan Bui, Michelle Sahagian, Olivia Kim-McManus, Aliya Frederick and 7 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Infantile epileptic spasms syndrome: Mechanisms and therapeutic approaches.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Austin LaytonDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Shifteh SattarDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Jong M RhoDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Jennifer H YangDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Jeffrey GoldDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Michael ZimbricDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Jonathan BuiDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Michelle SahagianDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Olivia Kim-McManusDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Aliya FrederickDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.ORCID 0000-0003-4389-9792
Natalie Guido-EstradaDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Anuja JindalDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Sarah WiegandDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Katherine DoveDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Marie SweatDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Mark NespecaDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.
Maria A MontenegroDepartment of Neurosciences, Rady Children's Hospital / University of California San Diego, San Diego, USA.ORCID 0000-0002-3609-2774

Funding

Child Neurologist Career Development Program (CNCDP)K12NS098482 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCHLAGGAR, BRADLEY L · 2016 to 2025
$26.2M
NINDS NIH HHS K12 NS098482NINDS NIH HHS L40 NS139363
6 · The paper itself

Abstract

Infantile epileptic spasms syndrome carries high morbidity and mortality compared with other childhood epilepsy syndromes. High-dose prednisolone is considered the first-line option by many neurologists, with efficacy comparable to adrenocorticotropic hormone (ACTH).  The second-line therapy is debated if prednisolone fails to induce remission. The objective of this study was to evaluate the efficacy of adrenocorticotropic hormone versus vigabatrin as second-line antiseizure medication in patients with infantile epileptic spasms syndrome after high-dose prednisolone failure. Thirty-eight patients met the inclusion criteria. Seventeen patients (45%) took vigabatrin and 21 (55%) took adrenocorticotropic hormone. There were no significant differences regarding age of infantile spasms onset (

Indexed as

Adrenocorticotropic HormoneAnticonvulsantsPrednisoloneSpasms, InfantileVigabatrinChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesTreatment FailureTreatment OutcomeAdrenocorticotropic HormoneAnticonvulsantsPrednisoloneVigabatrinACTHinfantile spasmsprednisolonevigabatrin

Identifiers

PMID40754938
PMCPMC13335130

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.