Evidence map›Paper›PMID 40754897›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2025

[Multi-omics analysis of the relationship between oxidative stress-related gene and prostate cancer].

J Ning, H Wang, S Luo, J Jing, J Wang, H Hou, M Liu

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J NingDepartment of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing 100005, China.
H WangDepartment of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing 100005, China.
S LuoDepartment of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing 100005, China.
J JingDepartment of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing 100005, China.
J WangDepartment of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing 100005, China.
H HouDepartment of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing 100005, China.
M LiuDepartment of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing 100005, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the relationship between oxidative stress-related genes and prostate cancer (PCa) from a multi-omics perspective using summary-data-based Mendelian randomization (SMR), colocalization analysis, and cellular experiments.

methodsSummary-level data on DNA methylation, gene expression, and circulating proteins were obtained and filtered. The PRACTICAL consortium was used as the discovery cohort, with the deCODE database serving as the validation cohort. SMR analysis and heterogeneity in dependent instruments (HEIDI) tests were conducted to assess the association and heterogeneity between oxidative stress-related genes and PCa. Colocalization analysis was performed to determine whether oxidative stress-related genes and PCa shared common causal variants. Finally, CCK-8 assays, wound healing assays, and Transwell invasion assays and Western blotting, were conducted to examine the effects of oxidative stress-related genes on the biological behavior of the PCa cell line C4-2.

resultsMulti-omics analysis identified

conclusionThrough integrated multi-omics analysis and experimental validation, this study confirmed a significant association between

Indexed as

Oxidative StressProstatic NeoplasmsCell Line, TumorDNA MethylationGlutathione S-Transferase piHumansMaleMendelian Randomization AnalysisMultiomicsGlutathione S-Transferase piGSTP1 protein, humanMendelian randomization analysisMulti-omics analysisOxidative stressProstatic neoplasms

Identifiers

PMID40754897
PMCPMC12330952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.