ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Sex-specific association of depressive symptom trajectories with cognitive decline and clinical progression in mild cognitive impairment.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Depression as a prognostic factor for conversion from mild cognitive impairment to all-cause dementia and Alzheimer's disease: a systematic review and meta-analysis of longitudinal studies.Frontiers in public health · 2026Pooled it
- Considerations in Alzheimer's Disease in Women.Current neurology and neuroscience reports · 2026Review
- Short-Term Changes in Depressive Symptoms Among Patients with Alzheimer's Disease Following a Precision Medicine Intervention.Brain sciences · 2025Article
- Sex-specific association of depressive symptom trajectories with cognitive decline and clinical progression in mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
introductionSex differences in the association between depressive symptoms and cognitive decline or dementia risk among older adults remain controversial. Reliance on single time point assessments of depressive symptoms, which fail to capture their dynamic course, may contribute to the inconsistencies.
methodsWe investigated the sex-specific associations of longitudinal trajectories of depressive symptoms with cognitive decline and progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia among 811 individuals with MCI.
resultsIn men, increasing depressive symptoms were associated with significantly steeper rates of cognitive decline, as measured by global cognitive and functional outcomes, and with an increased risk of dementia compared to consistently low depressive symptoms. In women, however, these associations were absent. Exploratory analyses using multiple specific cognitive domains as outcomes were also generally consistent with our main findings. DISCUSSION: These findings have critical implications for developing sex-specific, depression-targeted dementia prevention strategies. HIGHLIGHTS: We examined the sex-specific effects of depressive symptom trajectories on cognition and dementia risk in the Alzheimer's Disease Neuroimaging Initiative cohort. Increasing depressive symptoms were associated with cognitive and functional decline in men. Increasing depressive symptoms contributed to conversion to dementia in men. These associations were absent in women.
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