Evidence map›Paper›PMID 40754831›Full record

ArticleAutophagy2025

Autophagy suppression via SRC induction represents a therapeutic vulnerability for

Silvia Vega-Rubin-de-Celis, Amanda Kristani, Matthias Kudla, Svenja Mergener, Andrés Corrochano-Ruiz, Safa Larafa, Jetsy Montero-Vergara, Laura-Marie Ahle, Rainer Will, Mael Lever and 5 more

Abstract read
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Proteogenomic Analysis of HDAC4 and HDAC5 in Uveal Melanoma.Molecular medicine (Cambridge, Mass.) · 2026
    Article
  2. The latestExpert opinion on drug discovery · 2026
    Review
  3. Article
  4. Review
  5. The Biological Role and Clinical Significance of BECLIN-1 in Cancer.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Silvia Vega-Rubin-de-CelisInstitute for Cell Biology (Cancer Research), University Hospital Essen, Essen, Germany.ORCID 0000-0002-4196-8996
Amanda KristaniTranslational Genomics, German Cancer Consortium (DKTK) at University Hospital Essen, Essen, Germany.ORCID 0009-0008-4932-5208
Matthias KudlaInstitute for Cell Biology (Cancer Research), University Hospital Essen, Essen, Germany.ORCID 0000-0003-0733-9210
Svenja MergenerTranslational Genomics, German Cancer Consortium (DKTK) at University Hospital Essen, Essen, Germany.ORCID 0000-0002-0825-6938
Andrés Corrochano-RuizTranslational Genomics, German Cancer Consortium (DKTK) at University Hospital Essen, Essen, Germany.ORCID 0009-0000-0041-3006
Safa LarafaInstitute for Cell Biology (Cancer Research), University Hospital Essen, Essen, Germany.ORCID 0000-0001-5245-2373
Jetsy Montero-VergaraInstitute for Cell Biology (Cancer Research), University Hospital Essen, Essen, Germany.ORCID 0009-0008-6298-4830
Laura-Marie AhleDepartment of Ophthalmology, University Hospital Essen, Essen, Germany.ORCID 0009-0008-7987-1760
Rainer WillCore Facility Cellular Tools, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-6049-2690
Mael LeverDepartment of Ophthalmology, University Hospital Essen, Essen, Germany.ORCID 0000-0002-3244-6782
Viktor GrünwaldDepartment of Urology, University of Duisburg-Essen, and German Cancer Consortium (DKTK), University Hospital Essen, Essen, Germany.ORCID 0000-0003-2083-7687
Boris HadaschikDepartment of Urology, University of Duisburg-Essen, and German Cancer Consortium (DKTK), University Hospital Essen, Essen, Germany.ORCID 0000-0002-1052-2692
Verena JendrossekInstitute for Cell Biology (Cancer Research), University Hospital Essen, Essen, Germany.ORCID 0000-0003-1058-2107
Nikolaos E BechrakisDepartment of Ophthalmology, University Hospital Essen, Essen, Germany.ORCID 0000-0002-0180-1112
Samuel Peña-LlopisTranslational Genomics, German Cancer Consortium (DKTK) at University Hospital Essen, Essen, Germany.ORCID 0000-0003-3847-1353

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BAP1 is a tumor suppressor and epigenetic modifier that is frequently mutated in cancer, leading to increased aggressiveness and metastasis, as well as poor patient survival. Unfortunately, there are currently no specific therapies for metastatic tumors harboring

Indexed as

AutophagyMutationNeoplasmssrc-Family KinasesTumor Suppressor ProteinsUbiquitin ThiolesteraseAnimalsBeclin-1Cell Line, TumorChick EmbryoHumansProtein Kinase InhibitorsProto-Oncogene MasBAP1 protein, humanBeclin-1MAS1 protein, humanProtein Kinase InhibitorsProto-Oncogene Massrc-Family KinasesTumor Suppressor ProteinsUbiquitin ThiolesteraseBRCA1-associated protein 1cholangiocarcinomapatient-derived organoidsPDOspersonalized medicinetumoroids

Identifiers

PMID40754831
PMCPMC12758184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.