Evidence map›Paper›PMID 40754814›Full record

ArticleACS infectious diseases2025

Target-Based Design of Praziquantel Analogs at Cestode TRPM

Daniel J Sprague, Sang-Kyu Park, Marc Kaethner, Claudia M Rohr, Mina R Ghobrial, D Connor Barth, David Maillard, Thomas Spangenberg, Britta Lundström-Stadelmann, Jonathan S Marchant

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMInternational journal for parasitology. Drugs and drug resistance · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel J SpragueDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.ORCID 0000-0002-0709-3284
Sang-Kyu ParkDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
Marc KaethnerInstitute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Berne, Switzerland.
Claudia M RohrDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
Mina R GhobrialDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
D Connor BarthDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, United States.
David MaillardCentral Process Development - Downstream Processing Services, Merck Electronics KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany.ORCID 0000-0002-8244-4515
Thomas SpangenbergGlobal Health R&D of the Healthcare Business of Merck KGaA, Darmstadt, Germany, Ares Trading S.A. (an affiliate of Merck KGaA, Darmstadt, Germany), 1262 Eysins, Switzerland.ORCID 0000-0002-5654-8919
Britta Lundström-StadelmannInstitute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Berne, Switzerland.ORCID 0000-0003-2672-5766
Jonathan S MarchantDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.ORCID 0000-0001-6592-0877

Funding

Training in Signature Transdisciplinary Cardiovascular SciencesT32HL134643 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Justin L Grobe, Jacquelyn P Kulinski · 2017 to 2026
$4.2M
Resolving the properties of schistosome TRPMPZQ, the target of the anthelmintic drug praziquantelR01AI145871 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Wei Liu, JONATHAN S MARCHANT · 2020 to 2026
$3.1M
Functional interrogation of parasitic flatworm TRPM channels to identify novel anthelminticsF31AI183573 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Claudia M Rohr · 2024 to 2026
$149k
NHLBI NIH HHS T32 HL134643NIAID NIH HHS F31 AI183573NIAID NIH HHS R01 AI145871
6 · The paper itself

Abstract

The drug praziquantel (PZQ) has been used for decades to treat clinical and veterinary infections caused by parasitic flatworms. Although PZQ is efficacious against many different types of flukes and tapeworms, PZQ activity is lower against certain types of parasites, including pseudophyllidean cestodes. The target of PZQ is a parasitic flatworm transient receptor potential ion channel (TRPM

Indexed as

AnthelminticsCestodaHelminth ProteinsPraziquantelTransient Receptor Potential ChannelsAnimalsDrug DesignAnthelminticsHelminth ProteinsPraziquantelTransient Receptor Potential Channelsion channelparasitetapewormTRP channel

Identifiers

PMID40754814
PMCPMC12853403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.