Evidence map›Paper›PMID 40754803›Full record

ArticleBiomarkers in medicine2025

Plasma-derived circALG8 and circCAMTA1 as a panel for early diagnosis of non-small cell lung cancer.

Yufei Sheng, Lulu Yang, Boyang Wang, Zhiqi Hong, Jin Guo, Chengwei Zhou, Tao Li, Wentao Hu, Zhaohui Gong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yufei ShengDepartment of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Lulu YangDepartment of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Boyang WangDepartment of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Zhiqi HongDepartment of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Jin GuoDepartment of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Chengwei ZhouDepartment of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Tao LiHealth BioMed Co, Ltd, Ningbo, Zhejiang, China.
Wentao HuDepartment of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Zhaohui GongDepartment of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndogenous circular RNAs (circRNAs) have been implicated in the progression of cancer. This study aims to identify and evaluate the diagnostic efficacy of the newly found circALG8 and circCAMTA1 in patients with non-small cell lung cancer (NSCLC).

methodsDifferentially expressed circRNAs were identified through plasma circRNA sequencing, followed by validation in NSCLC tissues and plasma samples using RT-qPCR. The stability of circALG8 and circCAMTA1 was determined by RNase R and actinomycin D assays. Receiver operating characteristic (ROC) curve analysis was employed to evaluate the diagnostic performance of these circRNAs in comparison to traditional tumor biomarkers.

resultsBoth circALG8 and circCAMTA1 are significantly downregulated in tumor tissues and plasma from NSCLC patients, correlating closely with TNM staging. The two circRNAs are structurally stable circular RNA molecules, demonstrating considerable stability in plasma of NSCLC patients. The combined plasma circALG8 and circCAMTA1 hold the potential to serve as a diagnostic panel for early-stage NSCLC (AUC: 0.8987,

conclusionPlasma-derived circALG8 and circCAMTA1 May function as a diagnostic panel, thereby improving the diagnostic accuracy for early-stage NSCLC.

Indexed as

Biomarkers, TumorCarcinoma, Non-Small-Cell LungEarly Detection of CancerLung NeoplasmsRNA, CircularAgedFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoplasm StagingROC CurveBiomarkers, TumorRNA, CircularcircALG8circCAMTA1CircRNA panelearly-stagenon-small cell lung cancertradtional biomarker

Identifiers

PMID40754803
PMCPMC12416200

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.