Evidence map›Paper›PMID 40754751›Full record

ArticleJournal of applied toxicology : JAT2026

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model.

Kirthana Kunikullaya U, Zuzanna M Baran, Pascal Coumailleau, Laetitia Guillot, Harry W M Steinbusch, Fatima Smagulova, Thierry D Charlier

Abstract read
In one paragraph

Article in Journal of applied toxicology : JAT, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kirthana Kunikullaya UInserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), University of Rennes, Rennes, France.ORCID https://orcid.org/0000-0001-6150-5975
Zuzanna M BaranSimons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK.
Pascal CoumailleauInserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), University of Rennes, Rennes, France.
Laetitia GuillotInserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), University of Rennes, Rennes, France.
Harry W M SteinbuschPsychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
Fatima SmagulovaInserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), University of Rennes, Rennes, France.ORCID https://orcid.org/0000-0001-6883-1968
Thierry D CharlierInserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), University of Rennes, Rennes, France.

Funding

Écophyto Plan II Neo-ITI-2017French National Research Agency ANR-19-CE34-0005-05Region Bretagne SAD 2021 DISRUPT
6 · The paper itself

Abstract

Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates. This study investigated the developmental neurotoxicity of the neonicotinoid thiacloprid using two vertebrate models: zebrafish and mice. Transgenic cyp19a1b-GFP zebrafish eleutheroembryos, which report estrogenic activity, were exposed to thiacloprid (10

Indexed as

BrainInsecticidesNeonicotinoidsNeuronal PlasticityPrenatal Exposure Delayed EffectsThiazinesAnimalsAnimals, Genetically ModifiedBiomarkersFemaleMaleMiceNeurogenesisPregnancyZebrafishBiomarkersInsecticidesNeonicotinoidsthiaclopridThiazinesamygdalacerebellumhippocampushypothalamusmouseneonicotinoidneurogenesisneuroplasticitythiaclopridzebrafish

Identifiers

PMID40754751
PMCPMC12668873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.