ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2025
COX-2 in Fracture Callus Chondro-Osseous Junction Osteoclasts Regulates Chondrocyte Hypertrophy and Callus Vasculogenesis.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cyclooxygenase-2 (COX-2) activity is necessary for bone fracture healing to proceed normally. COX-2 is encoded by Ptgs2 and is expressed by several cell types during fracture healing, suggesting that COX-2 regulates multiple processes to affect fracture healing. Here, the role of COX-2 expression in osteoclasts during mouse femur fracture healing was examined. Mice lacking COX-2 (Ptgs2-cKO
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