Evidence map›Paper›PMID 40754673›Full record

ArticleBritish journal of haematology2025

Clonal haematopoiesis associates with distinct cytometric changes of red blood cells and platelets.

J B Salzbrunn, I A van Zeventer, A O de Graaf, S Klatte, L J van Pelt, P Kamphuis, M G J M van Bergen, A G Dinmohamed, B A van der Reijden, J Linssen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

J B SalzbrunnDepartment of Hematology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-3983-5385
I A van ZeventerDepartment of Hematology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-0771-1679
A O de GraafDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
S KlatteMedical Science Department, Sysmex Europe SE, Norderstedt, Germany.
L J van PeltDepartment of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
P KamphuisDepartment of Hematology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
M G J M van BergenDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
A G DinmohamedDepartment of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-4767-6716
B A van der ReijdenDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
J LinssenMedical Science Department, Sysmex Europe SE, Norderstedt, Germany.
J J SchuringaDepartment of Hematology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
J H JansenDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
G HulsDepartment of Hematology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Funding

Dutch Ministry of Economic AffairsDutch Ministry of Health, Welfare and SportEuropean Union's Horizon 2020 Research and Innovation Program 634789Groningen UniversityKWF Kankerbestrijding KWF10813University Medical Center Groningen (UMCG)
6 · The paper itself

Abstract

Individuals with macrocytosis or a high RDW are at increased risk of developing haematological malignancies. The mechanisms that mediate this association remain unknown but may involve the presence of clonal haematopoiesis (CH). Here, we performed targeted next-generation sequencing on all individuals ≥60 years with macrocytosis (MCV >100 fL; n = 269) or high RDW (RDW ≥16%; n = 242) and 1:2 age- and sex-matched controls from the population-based Lifelines cohort. Macrocytosis is not associated with CH or peripheral blood count abnormalities. In contrast, individuals with a high RDW were associated with an increased number of mutated genes, larger clone sizes and a high prevalence of blood count abnormalities. Interestingly, individuals with a high RDW and CH display a uniform population of red blood cells in the distribution plots, despite not all cells carrying the respective mutation, suggesting an indirect effect of CH on the red blood cell population. While macrocytosis is not associated with CH in general, SF3B1 mutations associate with an elevated MCV. Individuals with a combination of TET2 and SRSF2 mutations show marked disturbances in platelet morphology. In conclusion, cytometric parameters of peripheral blood cells may serve as early indicators of dysplastic changes and are associated with distinct mutational patterns in CH.

Indexed as

Blood PlateletsClonal HematopoiesisErythrocytesAgedAged, 80 and overCase-Control StudiesDioxygenasesErythrocyte IndicesFemaleHematologic NeoplasmsHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedMutationSerine-Arginine Splicing FactorsDioxygenasesSerine-Arginine Splicing FactorsSRSF2 protein, humanacute leukaemiaclinical haematologyclonal evolutionclonal haematopoiesisepidemiologygenetic analysis

Identifiers

PMID40754673
PMCPMC12436208

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.