ArticleScientific reports2025
Redox metabolic disruptions in the honey bee brain following acute exposure to the pyrethroid deltamethrin.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Disruption of Antioxidant Defense Systems in Honey Bees and Wild Bees Under Environmental Xenobiotic Pressure.Antioxidants (Basel, Switzerland) · 2026Review
- Sublethal Concentration of Chloramphenicol Threatens the Health ofInternational journal of molecular sciences · 2026Article
- Immune response in honey bees (Apis mellifera) following humic substance feeding.Veterinary research communications · 2026Article
- Metabolic Redox Modulation byMolecules (Basel, Switzerland) · 2026Article
- Prolonged Deltamethrin Exposure Induces Dose-Dependent Glycerol Overproduction and Efficient Deltamethrin Removal byMetabolites · 2026Article
- Behavioral disruption in honey bees (Apis mellifera) exposed to isolated and combined insecticides.Ecotoxicology (London, England) · 2026Article
- Analysis of Panels of Chemical Biomarkers in the Honeybee in Hemolymph and Fat Body in Response to Physiological and Environmental Factors.Metabolites · 2025Review
- Effect of Vitamin D Supplementation on Oxidative Stress Biomarkers in Women Following Religious or Intermittent Fasting Patterns.Nutrients · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deltamethrin is a widely used pyrethroid insecticide that has detrimental effects on the redox homeostasis of honey bee (Apis mellifera) brains. The decline of pollinating insect populations, including honey bee colonies, is a growing global concern. This problem results in serious ecological and economic concerns as well as veterinary- and animal health-related issues. In addition, exposure to agricultural pesticides is one of the major contributing factors. Adult worker honey bees were exposed to three sublethal concentrations of orally administered deltamethrin (1.975, 3.95, and 7.9 ng/bee/day; corresponding to LD50/40, LD50/20, and LD50/10) for 48 h. In this study, various redox markers, including glutathione concentrations, antioxidant enzyme activities, total antioxidant capacity, hydrogen peroxide concentrations and lipid peroxidation products, were monitored in brain homogenate samples from honey bees. The results revealed significant changes related to the glutathione system, as indicated by decreases in the GSH/GSSG ratio and GSH concentration in all treatment groups. The activities of the monitored enzymes, such as glucose-6-phosphate dehydrogenase (G6PDH), superoxide dismutase (SOD), and xanthine oxidase (XO), were significantly decreased, highlighting the altered function of the enzymatic antioxidant defense system. Moreover, pronounced lipid peroxidation was detected in the highest-dose group, as indicated by increased malondialdehyde (MDA) levels; however, H
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