Evidence map›Paper›PMID 40754615›Full record

ArticlePediatric surgery international2025

Residual nephrogenic rests affect the long-term prognosis of Wilms tumor with bilateral nephrogenic rests.

Xiaofeng Chang, Jinghao Yan, Shen Yang, Hong Qin, Wei Yang, Yang Yang, Yanchao Qu, Jianguo Zhang, Jiatong Xu, Tong Yu and 3 more

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Article in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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13 authors.

Xiaofeng Chang *Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Jinghao Yan *Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Shen Yang *Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Hong QinDepartment of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Wei YangDepartment of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Yang YangDepartment of Urology Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Yanchao QuDepartment of Urology Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Jianguo ZhangDepartment of Pediatric Surgery, Inner Mongolia Maternal and Child Health Care Hospital, Hohhot, 010020, China.
Jiatong XuDepartment of Pathology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Tong YuDepartment of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Han LiuDepartment of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Hongcheng SongDepartment of Urology Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. songhch1975@126.com.
Huanmin WangDepartment of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. wanghuanmin@bch.com.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe progression of nephrogenic rests (NRs) can lead to the development of Wilms tumor (WT). The aim is to explore the factors affecting the poor prognosis associated with WT combined with bilateral NRs.

methodsWe retrospectively analyzed the clinical data of patients with WT combined bilateral NRs admitted to our center from January 2008 to December 2022. The enrolled patients were divided into two groups according to whether they had residual NRs at the end of standard therapy or not.

results57 patients were finally enrolled in this study, of which 23 patients were in the non-residual NRs group and 34 patients were in the residual NRs group. In the residual NRs group, 15 patients (44.1%) ultimately progressed to WT, and 3 patients died of tumor. In the non-residual NRs group, 1 patient (4.3%) experienced WT development (P < 0.01). The 5-year EFS of the non-residual group was 95.6%, which was significantly higher than that of the residual group (70.5%) (p < 0.01). Univariate and multivariate Cox analysis revealed that residual NRs was the risk factor for WT progression in the WT patients with bilateral NRs.

conclusionThe residual NRs increased the risk of WT development and led to poor prognosis. Future multicenter prospective studies may need to further assess the conditions of patients with residual NRs to guide further treatment.

Indexed as

Kidney NeoplasmsWilms TumorChildChild, PreschoolDisease ProgressionFemaleHumansInfantMalePrognosisRetrospective StudiesRisk FactorsBilateralNephrogenic restsPrognosisResidualRisk factorWilms tumor

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PMID40754615

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