ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2025
Epigenetic manipulation of anterior insular cortex alters neural signals and cognitive control.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The balance between impulsive prepotent behavior and inhibition is a crucial aspect of self-control, and disruptions to this balance are observed in aging and various neuropsychiatric conditions, such as addiction. Both the insula and histone deacetylases (HDACs), a family of epigenetic enzymes, are implicated in these disruptions, with HDAC inhibitors showing therapeutic potential. However, the role of single neuron activity in the insula in relation to cognitive control and how this activity is affected by HDAC modulation in behaving animals remains unclear. In this study, we focus on HDAC5, a class II HDAC that regulates gene transcription and shuttles between the nucleus and cytoplasm in response to neuronal activity. We investigate how overexpression of nuclear-localized HDAC5 in the anterior insula influences cognitive control and associated neural processes in rats performing a STOP-change task. This task contrasts frequent prepotent responding (GO trials) with infrequent response inhibition and behavioral redirection (STOP-change trials). Our results show that HDAC5 overexpression altered neural activity linked to executive control signals in the anterior insula, leading to faster prepotent responses and a reduced capacity for behavioral inhibition (i.e., increased motor impulsivity). Additionally, while insula firing was influenced by trial history (i.e., previous trial rewarded or not), HDAC5 overexpression did not affect this feature. These findings suggest that increased HDAC5 activity impair cognitive control, and targeting HDAC5 in this region may offer a promising therapeutic approach for enhancing executive control and mitigating impulsivity-related cognitive, emotional, and social impairments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.