Evidence map›Paper›PMID 40754529›Full record

ArticleBMC biology2025

Non-invasive light flickering reinstates visual plasticity in adult mice via lipocalin 2.

Chenchen Ma, Zhenni Wang, Wei Wu, Xiao Ma, Laijian Wang, Xinxin Zhang, Wenjing Chen, Xi Kuang, Yufei Li, Ying Miao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chenchen MaCenter for Advanced Interdisciplinary Science and Biomedicine of IHM, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Zhenni WangCenter for Advanced Interdisciplinary Science and Biomedicine of IHM, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Wei WuCenter for Advanced Interdisciplinary Science and Biomedicine of IHM, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Xiao MaCenter for Advanced Interdisciplinary Science and Biomedicine of IHM, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Laijian WangDepartment of Anatomy, Neuroscience Laboratory for Cognitive and Developmental Disorders, Medical College of Jinan University, Guangzhou, Guangdong, 510630, China.
Xinxin ZhangCenter for Advanced Interdisciplinary Science and Biomedicine of IHM, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Wenjing ChenCenter for Advanced Interdisciplinary Science and Biomedicine of IHM, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Xi KuangCenter for Advanced Interdisciplinary Science and Biomedicine of IHM, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Yufei LiHefei National Research Center for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.
Ying MiaoHefei National Research Center for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.
Tian XueHefei National Research Center for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.
Bin JiangGuangdong Province Key Laboratory of Brain Function and Disease, Faculty of Forensic Medicine Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Yupeng YangCenter for Advanced Interdisciplinary Science and Biomedicine of IHM, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China. yangyp@ustc.edu.cn.

Funding

Center for Advanced Interdisciplinary Science and Biomedicine of IHM QYPY20230031
6 · The paper itself

Abstract

backgroundLight flickering, a non-invasive stimulation technique over recent years, has shown a promising therapeutic potential for brain dysfunctions. However, the mechanisms by which this visual stimulus exerts its beneficial effects are largely unknown.

resultsHere, we found that 7 days of 1 h 20 and 40 Hz light flickering promoted visual plasticity in primary visual cortex of adult mice. RNA sequencing results showed an increase in lipocalin 2 (LCN2) expression in the visual cortex following 20 or 40 Hz light flickering. By contrast, 80 Hz light flickering or constant light had no significant effect on either plasticity or LCN2 expression. LCN2 knock-down blocked light flickering-induced plasticity, while its overexpression mimicked the effects of light flickering. Moreover, the administration of minocycline blocked the plasticity induced by either light flickering or LCN2 overexpressing. Lastly, 40 Hz light flickering combined with reverse suture facilitated the recovery of the abnormal ocular dominance distribution in adult amblyopic mice.

conclusionsOur data indicate that non-invasive light flickering restores visual plasticity, mediated by LCN2 and microglia, providing new insights into the mechanism of light flickering.

Indexed as

LightLipocalin-2Neuronal PlasticityPhotic StimulationVisual CortexAnimalsMaleMiceMice, Inbred C57BLLcn2 protein, mouseLipocalin-2Light flickeringLipocalin-2MicrogliaOcular dominance plasticityVisual cortex

Identifiers

PMID40754529
PMCPMC12320347

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.