ArticleThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2025
Betamethasone latency period and neonatal hypoglycemia in term infants.
Article in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionInfants exposed to antenatal betamethasone (BMZ) between 34.0 and 36.6 weeks gestational age (GA) have increased risk for neonatal hypoglycemia, a known cause of brain injury. While a shorter latency period between BMZ administration and delivery is associated with an increased risk of neonatal hypoglycemia in late preterm infants, the impact of the BMZ latency period on neonatal hypoglycemia in infants born at term (≥37 weeks) has not been previously characterized. Term infants without additional risk factors such as growth restriction or maternal diabetes are not routinely screened and may be at risk for unrecognized neonatal hypoglycemia. The purpose of this study was to determine whether the latency period from antenatal BMZ administration to delivery impacts the incidence of neonatal hypoglycemia in term infants.
methodsThis retrospective cohort study analyzed maternal-infant dyads from the University of Minnesota Obstetric Measures database (January 2017-August 2023) who received BMZ during pregnancy and delivered at ≥37 weeks (
resultsThe most common indication for BMZ was pre-eclampsia/pregnancy-induced hypertension in the recent BMZ group and preterm labor with intact membranes in the remote BMZ group ( DISCUSSION: In this cohort of term infants, a shorter latency period between BMZ administration and delivery was not associated with increased incidence or treatment of hypoglycemia. However, the rate of hypoglycemia screening was low in both groups and rates of undiagnosed hypoglycemia in BMZ-exposed term neonates remain unknown. Prospective longitudinal studies aimed at characterizing the risk of hypoglycemia in term infants exposed to BMZ would be beneficial to inform hypoglycemia screening practices in BMZ-exposed neonates.
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