ArticleThe Journal of reproduction and development2025
Tryptophan promotes sperm hyperactivation in hamsters via 5-hydroxytryptamine biosynthesis within sperm.
Article in The Journal of reproduction and development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Large cyclic AMP-dependent increases in tyrosine-phosphorylated proteins are not absolutely necessary for the induction of full-type hyperactivation and penetration into eggs in ejaculated boar spermatozoa in vitro.The Journal of reproduction and development · 2026Article
- Development of an open-hardware semen homogenizer and application to serotonin effects on sperm motility.PloS one · 2025Article
- Influences of 5-Hydroxytryptamine Receptor Agonists on Spermatozoal Hyperactivation and In Vitro Fertilization Success in Mice.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
L-tryptophan (Trp), an essential amino acid, is a precursor of 5-hydroxytryptamine (5-HT; also known as serotonin) that promotes mammalian sperm hyperactivation. Since mammalian sperm contain Trp hydroxylase (TPH), they may contribute to 5‑HT biosynthesis. Therefore, this study aimed to examine the effect of Trp on hamster sperm hyperactivation and determine whether sperm are involved in 5-HT biosynthesis. Trp significantly enhanced sperm hyperactivation via the 5-HT
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