Evidence map›Paper›PMID 40754335›Full record

ArticleVox sanguinis2025

Exploring the influence of blood donor sex on outcomes in Australian very low birth weight infants.

Georgina Jacko, Aarany Sivakaanthan, Peter Cunningham, James Daly, Helen Liley

Abstract read
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Article in Vox sanguinis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Georgina JackoPathology and Clinical Governance, Australian Red Cross Lifeblood, Brisbane, Queensland, Australia.
Aarany SivakaanthanPaediatric Department, Children's Health Queensland, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0003-2510-7958
Peter CunninghamNeonatal Critical Care Unit, Mater Health, South Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0002-1915-702X
James DalyPathology and Clinical Governance, Australian Red Cross Lifeblood, Brisbane, Queensland, Australia.
Helen LileyNeonatal Critical Care Unit, Mater Health, South Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0002-8249-9516

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesDespite many known benefits of red blood cell (RBC) transfusions for very low birth weight (VLBW) infants, there is increasing concern that they may be associated with adverse clinical outcomes and that donor characteristics (including donor sex) could contribute to these adverse outcomes. MATERIALS AND

methodsOutcomes of a 7-year (2016-2022) retrospective cohort of VLBW preterm infants born at Mater Mothers' Hospital who received at least one RBC transfusion and no other blood products were assessed. While adjusting for the number of transfusions administered to each neonate, we investigated the association between donor sex (expressed as the proportion of transfused RBC units collected from female donors) and standardized morbidity outcomes that are reported to the Australian and New Zealand Neonatal Network. These outcomes include bronchopulmonary dysplasia, late onset infection, retinopathy of prematurity and mortality.

resultsAnalysis including 394 neonates who received a total of 820 RBC transfusions did not identify any statistically significant associations between blood donor sex and the outcomes of interest.

conclusionOur findings support the continued practice of administration of RBC transfusions to Australian VLBW neonates without consideration of blood donor sex. Further large, prospective, multi-centre studies are recommended to enhance the level of evidence addressing this clinical concern.

Indexed as

Blood DonorsErythrocyte TransfusionInfant, Very Low Birth WeightAustraliaBronchopulmonary DysplasiaFemaleHumansInfant, NewbornMaleRetrospective StudiesSex Factorsblood donor gendervery low birth weight (VLBW) infants

Identifiers

PMID40754335
PMCPMC12422830

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.