Evidence map›Paper›PMID 40754313›Full record

ArticleBone & joint open2025

Dual-mobIlity verSus conventional Total hip arthroplasty In femoral Neck fractures, a registry-nested, open-label, Cluster-randomized crossover Trial (DISTINCT) : statistical analysis plan.

DISTINCT Study Group, John E Farey, Tania Alland, Justine M Naylor, Thu-Lan Kelly, Kara Cashman, Michelle Lorimer, Carl Holder, Adriane M Lewin, Frances Garden and 8 more

Abstract read
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In one paragraph

Article in Bone & joint open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

DISTINCT Study Group
John E FareyInstitute for Musculoskeletal Health, King George V Building, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.
Tania AllandAustralian Orthopaedic Association National Joint Replacement Registry, South Australian Health and Medical Research Institute, Adelaide, South Australia.
Justine M NaylorWhitlam Orthopaedic Research Centre, Ingham Institute for Applied Medical Research, South Western Sydney Clinical School, University of New South Wales, Liverpool, Australia.
Thu-Lan KellySchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.
Kara CashmanSouth Australian Health and Medical Research Institute, Adelaide, Australia.
Michelle LorimerSouth Australian Health and Medical Research Institute, Adelaide, Australia.
Carl HolderSouth Australian Health and Medical Research Institute, Adelaide, Australia.
Adriane M LewinWhitlam Orthopaedic Research Centre, Ingham Institute for Applied Medical Research, South Western Sydney Clinical School, University of New South Wales, Liverpool, Australia.
Frances GardenWhitlam Orthopaedic Research Centre, Ingham Institute for Applied Medical Research, South Western Sydney Clinical School, University of New South Wales, Liverpool, Australia.
Chi Kin LawClinical Trials Centre, National Health and Medical Research Council, Sydney, Australia.
Jacqueline C T ClosePrince of Wales Clinical School, University of New South Wales, Randwick, Australia.
Stephen E GravesAustralian Orthopaedic Association National Joint Replacement Registry, South Australian Health and Medical Research Institute, Adelaide, South Australia.
Richard de SteigerDepartment of Surgery, Epworth Healthcare, University of Melbourne, Melbourne, Australia.
Peter L LewisAustralian Orthopaedic Association National Joint Replacement Registry, South Australian Health and Medical Research Institute, Adelaide, South Australia.
Sam AdieWhitlam Orthopaedic Research Centre, Ingham Institute for Applied Medical Research, South Western Sydney Clinical School, University of New South Wales, Liverpool, Australia.
Sanja LujicCentre for Big Data Research in Health, University of New South Wales, Sydney, Australia.
Ian A HarrisInstitute for Musculoskeletal Health, King George V Building, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.

Funding

Australian Orthopaedic AssociationAvant FoundationWhitlam Orthopaedic Research Centre
6 · The paper itself

Abstract

Aims: A statistical analysis plan for analysis of DISTINCT (Dual-mobIlity verSus conventional Total hip arthroplasty In femoral Neck fractures, a registry-nested, open-label, Cluster-randomized crossover Trial) is outlined to aid transparency in analytical procedures. Methods: DISTINCT aims to determine whether dual-mobility total hip arthroplasty (THA) is superior to conventional THA in reducing postoperative prosthetic hip dislocations in patients undergoing surgery for femoral neck fractures. The trial is nested within the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR). The clusters comprised hospitals that perform at least 12 THAs for femoral neck fracture per annum. Each hospital was randomized to two sequential periods of dual-mobility THA and conventional THA, with the order randomly allocated. Crossover occurred once sites had recruited an average of 16 patients eligible for the primary analysis in the initial allocation, to provide an average of 32 patients per cluster. The primary outcome is the incidence of prosthetic hip dislocation in the first postoperative year. Secondary outcomes are the rate of revision for dislocation, all-cause revision, mortality at one, two, and five years, and complication rates at one year. All analyses will use cluster summary methods, weighted by cluster size to account for unequal cluster sizes. Participants will be analyzed in the groups to which they were randomized (intention-to-treat). Sensitivity analyses will be performed to analyze the unadjusted primary outcome based on treatment received (as-treated) and per-protocol groupings. Conclusion: This statistical analysis plan describes the detailed analysis of the DISTINCT study, a registry-nested, open-label, cluster-randomized crossover trial that will provide supporting evidence for prosthesis choice in the common clinical problem of femoral neck fracture.

Identifiers

PMID40754313
PMCPMC12318617

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.