Evidence map›Paper›PMID 40754035›Full record

ArticleJournal of thrombosis and haemostasis : JTH2026

Development and validation of venous thromboembolism-bidirectional encoder representations from transformers (VTE-BERT) natural language processing model.

Omid Jafari, Shengling Ma, Barbara D Lam, Jun Y Jiang, Emily Zhou, Mrinal Ranjan, Justine Ryu, Raka Bandyo, Arash Maghsoudi, Bo Peng and 5 more

Abstract readValidation Study
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Omid JafariSection of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Shengling MaSection of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Barbara D LamDivision of Hematology and Oncology, Fred Hutch Cancer Center, University of Washington, Seattle, Washington, USA.
Jun Y JiangSection of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Emily ZhouMcGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Mrinal RanjanSection of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Justine RyuSection of Hematology, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Raka BandyoTegria Services Group, Dallas, Texas, USA; Harris Health System, Harris County, Texas, USA.
Arash MaghsoudiInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas, USA.
Bo PengCenter for Innovations in Quality, Effectiveness and Safety, Baylor College of Medicine, Houston, Texas, USA; Section of Epidemiology and Population Science, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Christopher I AmosCenter for Innovations in Quality, Effectiveness and Safety, Baylor College of Medicine, Houston, Texas, USA; Section of Epidemiology and Population Science, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Abiodun OluyomiSection of Epidemiology and Population Science, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Nathanael R FillmoreMassachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA; Veterans Affairs Boston Healthcare System, Harvard Medical School, Boston, Massachusetts, USA.
Jennifer LaMassachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA; Veterans Affairs Boston Healthcare System, Harvard Medical School, Boston, Massachusetts, USA.
Ang LiSection of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. Electronic address: ang.li2@bcm.edu.

Funding

AIM-AHEAD Coordinating Center - All Four CoresOT2OD032581 · OD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Paul Avillach, Bettina M. Beech · 2021 to 2026
$168.7M
Epidemiology and Biomarkers in Transplant Associated Thrombotic Microangiopathy (TA-TMA): A Prospective Validation Cohort StudyK23HL159271 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Ang Li · 2022 to 2026
$835k
NHLBI NIH HHS K23 HL159271NIH HHS OT2 OD032581
6 · The paper itself

Abstract

backgroundAccurate and rapid phenotyping of venous thromboembolism (VTE) in longitudinal studies is important. A natural language processing (NLP) tool externally validated in representative patients is lacking.

objectivesTo train and validate an efficient NLP model to detect incident VTE event.

methodsWe designed a novel NLP platform, NLPMed, to assist thrombosis researchers with data preprocessing, phenotype annotation, language model finetuning, and NLP application. Using clinical notes, discharge summaries, and radiology reports from patients with cancer at 2 healthcare institutions, we finetuned Bio_Clinical Bidirectional Encoder Representations from Transformers (BERT) to develop VTE-BERT. The new model was trained to detect acute VTE events and their anatomical locations longitudinally. We internally and externally validated the model's performance in 2 randomly sampled cohorts of patients with advanced cancer.

resultsThe training cohort consisted of 715 patients and 14 013 annotated notes with ≥1 VTE keyword from the Harris Health System. The internal validation cohort included 400 additional patients with 7190 VTE keyword-containing notes from Harris Health System. The external validation cohort included 400 patients with 7371 VTE keyword-containing notes from the national Veterans Affairs healthcare system. VTE-BERT was trained until it reached a precision of 95% and recall of 98% on the patient level. Using independent datasets, the model achieved precision and recall of 95% and 91% in internal validation and of 85% and 92% in external validation.

conclusionWe trained and externally validated an efficient NLP model to detect incident VTE events longitudinally. We believe its adoption will accelerate thrombosis research by improving VTE detection at scale and decreasing the time and expense involved with manual chart review in big data epidemiological studies.

Indexed as

Data MiningElectronic Health RecordsNatural Language ProcessingVenous ThromboembolismFemaleHumansMalePhenotypeReproducibility of Resultsartificial intelligencelarge language modelnatural language processingneoplasmsthromboembolism

Identifiers

PMID40754035
PMCPMC12360494

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.