Evidence map›Paper›PMID 40753574›Full record

ArticleCell reports2025

Aging-induced semaphorin 7a promotes TGF-β1-mediated cell plasticity and breast tumor metastases.

Kelsey T Kines, Heather R Fairchild, Alan M Elder, Lauren M Cozzens, Zachary P Strugar, Veronica M Wessells, Alexandria R Becks, Weston W Porter, Virginia F Borges, Traci R Lyons

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kelsey T KinesDivision of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Cancer Biology Graduate Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Heather R FairchildDivision of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Alan M ElderDivision of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Cancer Biology Graduate Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Lauren M CozzensDivision of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Cancer Biology Graduate Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Zachary P StrugarColorado College, Colorado Springs, CO 80946, USA.
Veronica M WessellsDivision of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Alexandria R BecksDivision of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Cancer Biology Graduate Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Weston W PorterDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA.
Virginia F BorgesDivision of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Young Women's Breast Cancer Translational Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Cancer Center, Aurora, CO 80045, USA.
Traci R LyonsDivision of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Cancer Biology Graduate Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Young Women's Breast Cancer Translational Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Cancer Center, Aurora, CO 80045, USA. Electronic address: traci.lyons@cuanschutz.edu.

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Transgenic and Gene Targeting CoreP30AR057212 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI HOGAN, CHRISTOPHER J · 2009 to 2018
$6.2M
Colorado REACH HubU01HL152405 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DUKE, RICHARD C · 2019 to 2022
$5.1M
Medical Scientist Training ProgramT32GM149361 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI PATRICK J HU · 2023 to 2026
$4.5M
SEMA7A in postpartum mammary gland development and cellular transformationR01HD108335 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Traci Lyons · 2022 to 2026
$2.0M
Deciphering COX-2/SEMA7A dependent mechanisms of breast tumor progression.R01CA211696 · NCI · UNIVERSITY OF COLORADO DENVER · PI LYONS, TRACI · 2017 to 2021
$2.0M
A SIM2s/SEMA7A Switch Drives ER+ Breast Cancer ProgressionR01CA282900 · NCI · UNIVERSITY OF COLORADO DENVER · PI VIRGINIA F. BORGES, Traci Lyons · 2024 to 2026
$1.7M
Multi-Modal Optical/ microCT system for Colorado Animal Imaging ResourceS10OD027023 · OD · UNIVERSITY OF COLORADO DENVER · PI SERKOVA, NATALIE J. · 2020 to 2020
$733k
NCI NIH HHS P30 CA046934NCI NIH HHS R01 CA211696NCI NIH HHS R01 CA282900NHLBI NIH HHS U01 HL152405NIAMS NIH HHS P30 AR057212NICHD NIH HHS R01 HD108335NIGMS NIH HHS T32 GM149361NIH HHS S10 OD027023
6 · The paper itself

Abstract

Breast cancer risk is transiently increased in postpartum women, and this risk is prolonged in women whose first childbirth occurs after age 30. We observe elevated semaphorin 7a (SEMA7A) in tumor tissues from patients with breast cancer aged 31-39 diagnosed <10 years after childbirth. In the aged normal murine mammary gland, transforming growth factor β+ (TGF-β+) cells have increased levels of surface SEAM7A compared to the young. TGF-β1 induces SEMA7A expression in non-transformed mammary epithelial and breast cancer cells via multiple mechanisms. In mouse mammary tumor models, we observe accelerated tumor growth and metastases, increased TGF-β+SEMA7A+ cells, and epithelial-to-mesenchymal plasticity in aged mice. SEMA7A knockout and heterozygous littermates reveal that these phenotypes depend on SEMA7A in the host. We further show SEMA7A's pro-metastatic phenotype and abrogate it via a function-blocking antibody. Collectively, these results highlight the impact aging has on the mammary gland and the risk for breast cancer tumorigenesis.

Indexed as

AgingAntigens, CDBreast NeoplasmsCell PlasticitySemaphorinsTransforming Growth Factor beta1AdultAnimalsCell Line, TumorEpithelial-Mesenchymal TransitionFemaleGPI-Linked ProteinsHumansMiceMice, KnockoutNeoplasm MetastasisAntigens, CDGPI-Linked ProteinsSEMA7A protein, humanSema7a protein, mouseSemaphorinsTransforming Growth Factor beta1agingbreast cancerCP: CancerEMTepithelial-mesenchymal plasticitymetastasispostpartum breast cancerSEMA7ATGF-β

Identifiers

PMID40753574
PMCPMC12634057

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.