Evidence map›Paper›PMID 40753415›Full record

ArticleBMC pregnancy and childbirth2025

Intermittent preventive treatment, malaria, HIV, hepatitis and pregnancy outcomes in Nigerian women: a cross-sectional study in two healthcare facilities.

Rebecca Chinyelu Chukwuanukwu, George Uchenna Eleje, Felix Emeka Menkiti, Golibe Christian Ikpeze, Chioma Ngozichukwu Mbachu, Nnaedozie Paul Obiegbu, Confidence Chinaza Ogbomade, Hatesin Ifeanyi Anyaegbu, Alfred Friday Ehiaghe, Dorothy Amauche Ezeagwuna and 10 more

Abstract readMulticenter Study
In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Rebecca Chinyelu ChukwuanukwuDepartment of Immunology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria. rc.chukwuanukwu@unizik.edu.ng.
George Uchenna ElejeDepartment of Obstetrics & Gynaecology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria.
Felix Emeka MenkitiDepartment of Anatomic Pathology and Forensic Medicine, Nnamdi Azikiwe University, Awka, Nigeria.
Golibe Christian IkpezeDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Chioma Ngozichukwu MbachuDepartment of Paediatrics, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Nigeria.
Nnaedozie Paul ObiegbuDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Confidence Chinaza OgbomadeDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Hatesin Ifeanyi AnyaegbuDepartment of Immunology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.
Alfred Friday EhiagheDepartment of Immunology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.
Dorothy Amauche EzeagwunaDepartment of Parasitology & Entomology, Faculty of Bioscience, Nnamdi Azikiwe University, Awka, Nigeria.
Chidi Callistus EfobiDepartment of Haematology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.
Emmanuel Chukwubuikem EgwuatuDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Kezie Kenneth OrjintaDepartment of Human Nutrition and Dietetics, Nnamdi Azikiwe University, Awka, Nigeria.
John Emeka JamesDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Chiemezie Mac-Kingsley AgbanuDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Chinyere Ukamaka OnubuoguDepartment of Paediatrics, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Nigeria.
Onochie Bruno EzenwaDepartment of Histopathology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Chidimma Donatus OkaforDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Kenechukwu Stanley OnahDepartment of Paediatrics, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Nigeria.
Titus Osita ChukwuanukwuSurgery Department, Nnamdi Azikiwe University, Awka, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria infection during pregnancy remains a public health concern. Malaria prevention strategies, including chemoprevention, are recommended during pregnancy. This study was conducted to assess the use of intermittent preventive treatment for malaria during pregnancy (IPTp), the prevalence of malaria, HIV, and hepatitis infections and the occurrence of premature rupture of membranes (PROM) among pregnant women in two healthcare facilities in south-eastern Nigeria.

methodsA dual hospital-based cross-sectional study was conducted in two hospitals in Anambra State, Nigeria. Pregnant women who provided informed consent were recruited. Blood samples were collected to test for HIV, malaria, hepatitis B and C virus infections.

resultsAmong the 134 participants enrolled, 8 (5.97%) tested positive for malaria, 5 (3.73%) for HIV, and 6 (4.47%) for hepatitis B; preeclampsia was observed in 5 women (3.73%), and 3 (2.24%) experienced PROM. The use of IPTp was relatively high at 73.9%. Preterm deliveries accounted for 5.2% of the cases.

conclusionA lower prevalence of malaria was observed in this study than in previous reports in the region, likely due to the high implementation of IPTp. These findings emphasize the role of IPTp in reducing malaria among pregnant women and provide useful data on HIV, hepatitis and PROM prevalence in the study population.

Indexed as

AntimalarialsHepatitis BHIV InfectionsMalariaPregnancy Complications, InfectiousPregnancy Complications, ParasiticAdolescentAdultCross-Sectional StudiesFemaleHepatitis CHumansNigeriaPre-EclampsiaPregnancyPregnancy OutcomeAntimalarialsHepatitisHIVIPTpMalariaPreeclampsiaPROM

Identifiers

PMID40753415
PMCPMC12318387

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.