Trial reportJournal of neuroengineering and rehabilitation2025
High-intensity interval training with robot-assisted gait therapy vs. treadmill gait therapy in chronic stroke: a randomized controlled trial.
Trial report in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative effectiveness of exercise interventions on postural balance and activity ability in stroke patients: a systematic review and network meta-analysis.BMC neurology · 2026Pooled it
- Effectiveness and safety of a lower-limb walking assist device for motor function recovery in subacute stroke patients: A prospective, randomized, open, parallel-controlled, noninferiority study.The Journal of international medical research · 2025Trial
- Comparative Efficacy of Exercise Modalities for Motor Function Recovery After Acute Ischemic Stroke: A Systematic Review and Bayesian Network Meta-Analysis.Life (Basel, Switzerland) · 2026Review
- High-Intensity Interval Training on Cardiorespiratory Fitness, Cognitive Function, and Functional Capacity in Adults with Stroke: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveStroke is a leading cause of long-term disability, significantly impacting patients' mobility and quality of life. Robot-assisted gait therapy (RAGT) and high-intensity interval training (HIIT) have individually shown potential in improving gait function in chronic stroke patients. This study investigated the potential effectiveness of combining high-intensity interval training (HIIT) with robot-assisted gait therapy (RAGT) to enhance gait, balance, and lower limb function in patients with chronic stroke.
methodsA randomized controlled trial was conducted with 48 patients with chronic stroke, of whom 44 patients (91.7%) completed the study. Participants were randomly assigned to a control group (treadmill-based gait therapy) or an intervention group (RAGT with HIIT using an end-effector robot). Both groups trained for 30 min, three times weekly, over 8 weeks. HIIT alternated between moderate and high intensities. Outcomes included the 10-meter walk test (10MWT), Functional Ambulation Category (FAC), Berg Balance Scale (BBS), Fugl-Meyer Assessment- Lower Extremity (FMA-LE), VO₂max, Modified Barthel Index (MBI), and lean body mass.
resultsBetween-group comparisons showed significant improvements in the intervention group in 10MWT (p < 0.001, d = 1.2), FAC (p = 0.009), BBS (p = 0.015), 2MWT (p = 0.005), and FMA-LE (p < 0.001) scores. Additionally, the intervention group demonstrated enhanced 2MWT (p < 0.001) and VO₂max (p = 0.005) within group; however, lean body mass within-group changes were minor in both groups. The superior outcomes in the intervention group highlight the potential combined benefits of combining HIIT with RAGT for intensive, repetitive, and task-specific training.
conclusionHIIT integrated with RAGT may be an effective approach for improving the gait and functional outcomes of patients with chronic stroke. This novel combination shows promise for enhancing rehabilitation strategies, with potential implications for optimizing functional recovery and quality of life.
trial registrationThe study was registered with the Clinical Research Information Service (KCT0007659).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.