ArticleBMC genomics2025
A Candidatus liberibacter Asiaticus effector, CLIBASIA_00185 controls sugar metabolism, phenylpropanoid biosynthesis, and endocytosis pathway in Citrus sinensis.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A small peptide APP3-14 disrupts pathogen-insect mutualism by modulating plant MYC2-mediated olfactory defense.Plant communications · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundCitrus Huanglongbing (HLB) is the most catastrophic citrus disease worldwide. SEC-dependent effectors (SDEs) play prominent roles in HLB pathogenesis, and 86 were predicted from the genome of Candidatus Liberibacter asiaticus. Nevertheless, little is known about the comprehensive picture of effector action mechanisms. In this study, RNA-seq was performed to explore the gene expression profiling of transgenic citrus plants expressing a CLas SDE, CLIBASIA_00185 (0185-OE).
resultsA total of 6,506 differentially expressed genes (DEGs) were identified between 0185-OEs and the wild-type (WT) control through RNA-seq. Gene ontology (GO) analysis indicated that molecular functions associated with cellular process, cell part, binding, and catalysis activity were affected. Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis revealed that DEGs were enriched in pathways including primary and secondary metabolisms. Further analysis demonstrated that DEGs implicated in sugar metabolism, phenylpropanoid biosynthesis, and endocytosis pathway were markedly induced in 0185-OE group compared to those in WTs. Ten genes were chosen to verify RNA-seq data with qRT-PCR, and their expression patterns were in good agreement with those of RNA-seq.
conclusionsThe transcriptomic analysis demonstrated that CLIBASIA_00185 (CLas0185) governed sugar metabolism, phenylpropanoid biosynthesis and endocytosis for pathogen survival and development. The results determined a prominent role of CLas0185 in HLB pathogenicity that could be a target for disease management.
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