Evidence map›Paper›PMID 40753366›Full record

ArticleBMC cardiovascular disorders2025

Accuracy and reliability of non-invasive pressure-strain loop for myocardial work assessment in functional single ventricle patients.

Mengqian Liao, Xuechen Liu, Junxiang Pan, Tianhao Liao, Xuan Li, Zonghui Hou, Jian Cui, Lianyi Wang

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mengqian Liao *Heart Center, The First Hospital of Tsinghua University, No.6, First Street of Jiuxianqiao, Beijing, 100016, China.
Xuechen Liu *Heart Center, The First Hospital of Tsinghua University, No.6, First Street of Jiuxianqiao, Beijing, 100016, China.
Junxiang PanHeart Center, The First Hospital of Tsinghua University, No.6, First Street of Jiuxianqiao, Beijing, 100016, China.
Tianhao LiaoThe First Clinical Institute, Zunyi Medical University, Zunyi, 563000, China.
Xuan LiSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, 610000, China.
Zonghui HouHeart Center, The First Hospital of Tsinghua University, No.6, First Street of Jiuxianqiao, Beijing, 100016, China.
Jian CuiHeart Center, The First Hospital of Tsinghua University, No.6, First Street of Jiuxianqiao, Beijing, 100016, China. 13621361740@qq.com.
Lianyi WangHeart Center, The First Hospital of Tsinghua University, No.6, First Street of Jiuxianqiao, Beijing, 100016, China. lywang@mail.tsinghua.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn biventricular circulation, myocardial work indices derived from pressure-strain loops (PSL) show potential for effectively evaluating ventricular function in both left and right ventricles. However, these novel myocardial work parameters have not been extensively investigated in patients with functional single ventricle (FSV).

objectivesTo assess the relationship between myocardial work indices and parameters from cardiac catheterization in FSV patients, and to compare differences between functional single ventricle subtypes.

methodsThis retrospective study analyzed 38 FSV patients, including 17 with single left ventricle (SLV) patients and 21 with single right ventricle (SRV) patients. All patients underwent echocardiography and cardiac catheterization on the same day. To analyze correlations, Spearman’s rank correlation coefficient was applied, while receiver operating characteristic (ROC) curves were developed to evaluate predictive accuracy.

resultsCompared to SLV patients, SRV patients exhibited significantly higher global wasted work (GWW) (194.0 [132.5, 309.5] vs. 101.0 [66.5, 143.5] mmHg%, p = 0.012) accompanied by significantly reduced global work efficiency (GWE) (86.0% [81.5, 90.0] vs. 93.0% [89.5, 95.0], p = 0.004). In all FSV patients, global work index (GWI) (r=-0.540, p < 0.01), global constructive work (GCW) (r=-0.436, p < 0.01), and GWE (r=-0.831, p < 0.001) showed significant negative correlations with ventricular end-diastolic pressure (VEDP), while GWW demonstrated a significant positive correlation with VEDP (r = 0.738, p < 0.001). PSL parameters exhibited good intra- and inter-observer reproducibility and high predictive value for VEDP > 10 mmHg.

conclusionsPressure-strain loop indices can effectively evaluate cardiac function in FSV patients and reveal functional differences between subtypes. Larger studies are needed to validate the value of these emerging indicators.

Indexed as

Cardiac CatheterizationHeart Defects, CongenitalHeart VentriclesMyocardial ContractionVentricular Function, LeftVentricular Function, RightVentricular PressureAdultFemaleGlobal Longitudinal StrainHumansMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsRetrospective StudiesFunctional single ventricleMyocardial workPressure-strain loopVentricular function

Identifiers

PMID40753366
PMCPMC12318391

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.