Efficient enamel subsurface lesion remineralisation and dentine tubule occlusion by high concentration CPP-ACP: a randomised, cross-over in situ study.

Peiyan Shen, James R Fernando, Yi Yuan, Coralie Reynolds, Geoffrey G Adams, Eric C Reynolds

Abstract readRandomized Controlled Trial

In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Peiyan ShenMelbourne Dental School, Oral Health CRC, The University of Melbourne, Melbourne, VIC, 3010, Australia.

James R FernandoMelbourne Dental School, Oral Health CRC, The University of Melbourne, Melbourne, VIC, 3010, Australia.

Yi YuanMelbourne Dental School, Oral Health CRC, The University of Melbourne, Melbourne, VIC, 3010, Australia.

Coralie ReynoldsMelbourne Dental School, Oral Health CRC, The University of Melbourne, Melbourne, VIC, 3010, Australia.

Geoffrey G AdamsMelbourne Dental School, Oral Health CRC, The University of Melbourne, Melbourne, VIC, 3010, Australia.

Eric C ReynoldsMelbourne Dental School, Oral Health CRC, The University of Melbourne, Melbourne, VIC, 3010, Australia. e.reynolds@unimelb.edu.au.ORCID http://orcid.org/0000-0002-6618-4856

Funding

National Health & Medical Research Council Australia 2000088

6 · The paper itself

Abstract

This study assessed the efficacy of 60% CPP-ACP to remineralise white spot lesions (WSLs) in enamel and to occlude patent dentinal tubules in a double-blind, randomized, cross-over, in situ study. Human enamel specimens with subsurface lesions (WSLs) and root dentine specimens with open dentinal tubules were prepared and inserted into intra-oral appliances worn by volunteers. Participants wore the appliances 24 h a day for four 14-consecutive day treatment periods with a 7-day washout period between treatments. Four treatments applied with a micro-brush once daily were 60% CPP-ACP with and without 1100ppm F as SnF

Indexed as

CaseinsDental CariesDental EnamelDentinTooth RemineralizationAdultCross-Over StudiesDouble-Blind MethodFemaleHumansMaleYoung Adultcasein phosphopeptide-amorphous calcium phosphate nanocomplexCaseinsCasein phosphopeptide-amorphous calcium phosphateEnamelFluorideRemineralisationStannous

Identifiers

PMID40753323

DOI10.1038/s41598-025-14005-z

PMCPMC12318122

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.