ArticleClinical and experimental medicine2025
Identification of prognostic genes related to T cell proliferation in papillary thyroid cancer based on single-cell RNA sequencing and bulk RNA sequencing data.
Article in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- KLRB1 gene in tumor immune regulation and disease prognosis: a multidimensional role review.Discover oncology · 2026Review
- Advances in immunotherapy for thyroid malignancies: from molecular targets to clinical outcomes.Frontiers in medicine · 2026Review
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Authors and funding
7 authors.
Funding
Abstract
Papillary thyroid carcinoma (PTC) is the main pathological subtype of thyroid cancer. Given the strong association between T cells and PTC, this study focused on the prognostic value and potential molecular mechanisms of T cell proliferation-related genes (TPRGs) in PTC. ScRNA-seq data were analyzed to identify key cells and subpopulations based on public databases. Candidate genes were determined by intersecting differentially expressed genes (DEGs) from differential expression analysis of key subpopulations, high- and low-TPRGs score groups, and bulk RNA-seq data. Prognostic genes were then determined via Cox regression and a machine learning algorithm. A risk model was formed. PTC patients were grouped into high-risk and low-risk groups by risk score. Subsequently, the immune microenvironment was analyzed. Finally, cell communication analysis and pseudotime analysis were accomplished. T/NK cells were selected as key cells. Moreover, CD4
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