Evidence map›Paper›PMID 40753305›Full record

ArticleNPJ precision oncology2025

Multimodal tumor microenvironment signature of colorectal cancer for prediction prognosis and chemotherapy benefit.

Wei Jiang, Kun Yang, Chanchan Xiao, Hongli Ji, Botao Yan, Shuhan Zhao, Biao Zhang, Jiaxin Cheng, Shuoyu Xu, Guangxing Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wei Jiang *Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, P. R. China. jiangweinf@163.com.
Kun Yang *Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, P. R. China.
Chanchan Xiao *The First Affiliated Hospital, Jinan University, 510632, Guangzhou, P. R. China.
Hongli Ji *Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, P. R. China.
Botao YanDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, P. R. China.
Shuhan ZhaoDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, P. R. China.
Biao ZhangDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, P. R. China.
Jiaxin ChengDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, P. R. China.
Shuoyu XuDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, P. R. China.
Guangxing WangSchool of Science, Jimei University, 361021, Xiamen, P. R. China.
Zexi LinSchool of Science, Jimei University, 361021, Xiamen, P. R. China.
Jianping LuDepartment of Pathology, The Affiliated Cancer Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, 350014, Fuzhou, P. R. China.
Gang ChenDepartment of Pathology, The Affiliated Cancer Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, 350014, Fuzhou, P. R. China. naichengang@126.com.
Shuangmu ZhuoSchool of Science, Jimei University, 361021, Xiamen, P. R. China. shuangmuzhuo@jmu.edu.cn.
Jun YanDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, P. R. China. yanjunfudan@163.com.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2025A1515010448Basic and Applied Basic Research Foundation of Guangdong Province 2025A1515011769Fellowship of China Postdoctoral Science Foundation 2023TQ0136Fellowship of China Postdoctoral Science Foundation 2024M751321Fujian Province University-Industry Cooperation Project 2024Y4018Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Cancer 2020B121201004Joint Funds for the innovation of Science and Technology, Fujian province 2024Y9282National Natural Science Foundation of China 62375104National Natural Science Foundation of China 82273360Postdoctoral Fellowship Program of CPSF GZC20231069President Foundation of Nanfang Hospital, Southern Medical University 2023B016
6 · The paper itself

Abstract

The current tumor‒node‒metastasis (TNM) staging system cannot provide sufficient information for prognosis and chemotherapy benefits in patients with colorectal cancer (CRC). The tumor microenvironment plays a critical role in disease progression and therapeutic response. Here, we developed and validated a multimodal tumor microenvironment signature of CRC (MTMS

Identifiers

PMID40753305
PMCPMC12318095

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.