Evidence map›Paper›PMID 40753261›Full record

ArticleScientific reports2025

Establishment of THTT derivatives as potential antileishmanial and anti-inflammatory agents through in vitro and in silico investigations.

Sarah Sarwar, Rehana Masood, Huma Khan, Haleema Ali, Said Hassan, Ajaz Ahmad, Syed Sikandar Shah, Naveed Khan, Rasool Khan, Ho Soonmin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sarah SarwarDepartment of Biotechnology, Abdul Wali Khan University Mardan, Mardan, KP, Pakistan. sarasarwar86@gmail.com.
Rehana MasoodDepartment of Biochemistry, Shaheed Benazir Bhutto Women University, Peshawar, KP, Pakistan. rehana.masood@sbbwu.edu.pk.
Huma KhanDepartment of Biochemistry, Abdul Wali Khan University Mardan, Mardan, KP, Pakistan.
Haleema AliInstitute of Chemical Sciences, University of Peshawar, Peshawar, KP, Pakistan.
Said HassanDepartment of Health and Biological Sciences, Abasyn University Peshawar, Peshawar, 25000, KP, Pakistan.
Ajaz AhmadDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University Riyad, 11451, Riyadh, Saudi Arabia.
Syed Sikandar ShahDepartment of Clinical Pharmacy and Pharmacology, RAK College of Pharmacy, RAK Medical and Health Sciences University, Ras Al KHaimah, Ras Al Khaimah, 11172, UAE.
Naveed KhanDepartment of Biotechnology, Abdul Wali Khan University Mardan, Mardan, KP, Pakistan.
Rasool KhanInstitute of Chemical Sciences, University of Peshawar, Peshawar, KP, Pakistan.
Ho SoonminFaculty of Health and Life Sciences, INTI International University, 71800, Putra Nilai, Negeri Sembilan, Malaysia.
Nadeem UllahDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Nazif UllahDepartment of Biotechnology, Abdul Wali Khan University Mardan, Mardan, KP, Pakistan. ullahnazif@awkum.edu.pk.

Funding

King Saud University, Riyadh, Saudi Arabia ORF-2025-350
6 · The paper itself

Abstract

Cutaneous leishmaniasis, a neglected tropical disease (NTD) caused by Leishmania tropica, Leishmania major and other members of the same species, poses significant challenges in the public health sector, especially in developing countries. The limitations of current treatments, including toxicity, resistance, availability, and cost effectiveness, necessitate the development of novel therapeutics. This study investigated the leishmanicidal potential of five Thiadiazine thione derivatives (THTT) against L. tropica, at a dose range of 25-426 µM using an MTT assay. Compounds T9, T24, T25 (tris-THTT) and PG (mono-THTT) exhibited notable IC

Indexed as

Anti-Inflammatory AgentsAntiprotozoal AgentsLeishmania tropicaThionesAnimalsComputer SimulationHumansMiceMolecular Docking SimulationAnti-Inflammatory AgentsAntiprotozoal AgentsThionesAntiCytotoxicityInflammatoryIn vitro and in silico activityLeishmania tropicaPublic healthThiadiazine thione derivatives

Identifiers

PMID40753261
PMCPMC12318077

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.