ArticleJournal of orthopaedic surgery and research2025
The bibliometric and visualization analysis of alcohol-induced osteonecrosis of the femoral head: research trends and future directions (1998-2024).
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A bioactive magnesium alloy scaffold integrated with BMSCs-Loaded 3D microspheres synergistically promotes femoral head osteonecrosis repair by improving the osteogenic-angiogenic microenvironment.Bioactive materials · 2026Article
- The role of post-translational modifications in osteonecrosis of the femoral head.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundOsteonecrosis of the femoral head (ONFH) is a progressive, debilitating orthopedic condition that primarily results from compromised vascular supply. Chronic alcohol intake is a well-established non-traumatic etiological factor in ONFH. Despite the increasing global research on ONFH, a bibliometric analysis using explicit literature searches in Web of Science reveals that no studies have specifically focused on alcohol-induced osteonecrosis of the femoral head (AONFH). This study aims to provide a comprehensive overview of the global research landscape of AONFH, identifying key research hotspots, emerging trends, and future directions using both qualitative and quantitative bibliometric methods.
methodsThe Web of Science Core Collection was systematically searched for publications from 1998 to 2024 related to AONFH and identified 353 relevant articles. RStudio and Bibliometrix 4.1.0 were used to analyze annual publication volume and cited papers. VOSviewer was employed to conduct bibliographic coupling analysis and CiteSpace was used to analyze countries, institutions, authors, journals, and keywords. Microsoft Excel 2019 was utilized to perform linear regression on annual publication volume.
resultsClinical Orthopaedics and Related Research had the highest number of publications and citations. Chinese scholars published the most, while U.S.-based research received greater international recognition. Shanghai Jiao Tong University ranked first in institutional output. Sugano Nobuhiko and Fukushima Wakaba were identified as the most influential scholars. The main research hotspots-as measured by keyword centrality and frequency-were "risk factors" and "core decompression," followed by "total hip arthroplasty," "alcohol intake," and "steroid-induced osteonecrosis." Over time, the focus of AONFH research has shifted from broader themes such as "disease," "smoking," "occupational status," and "idiopathic osteonecrosis" to more specialized areas including "gene expression," "polymorphisms," "steroid-induced osteonecrosis," and "risk factors."
conclusionAONFH research has progressed significantly, especially with its transition from basic science to precision medicine, including innovations such as genomics and stem cell therapy. Early diagnosis and intervention are critical to improving outcomes. Future research is expected to focus on refining the identification of risk factors, optimizing core decompression techniques, and incorporating precision medicine to enhance the quality of life and long-term prognosis of patients with AONFH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.