Evidence map›Paper›PMID 40753252›Full record

ArticleCell communication and signaling : CCS2025

The crucial role of intercellular calcium wave propagation triggered by influenza A virus in promoting infection.

Fumiya Kozawa, Tomokazu Tamura, Naoki Takahashi, Taishi Kakizuka, Taro Ichimura, Rumi Shimada, Yasuyuki Hashimoto, Hironoshin Onizuska, Sayaka Kashiwagi, Tomoko Kamasaki and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fumiya KozawaDepartment of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, 060-8638, Japan.
Tomokazu TamuraDepartment of Microbiology and Immunology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, 060-8638, Japan.
Naoki TakahashiDepartment of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, 060-8638, Japan.
Taishi KakizukaSANKEN (The Institute of Scientific and Industrial Research), Osaka University, Mihogaoka 8‑1, Ibaraki, 567‑0047, Osaka, Japan.
Taro IchimuraTransdimensional Life Imaging Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Yamadaoka 2‑1, Suita, 565‑0871, Osaka, Japan.
Rumi ShimadaDepartment of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, 060-8638, Japan.
Yasuyuki HashimotoDepartment of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, 060-8638, Japan.
Hironoshin OnizuskaDepartment of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, 060-8638, Japan.
Sayaka KashiwagiDepartment of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, 060-8638, Japan.
Tomoko KamasakiDepartment of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, 060-8638, Japan.
Maho AmanoDepartment of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, 060-8638, Japan.
Takeharu NagaiSANKEN (The Institute of Scientific and Industrial Research), Osaka University, Mihogaoka 8‑1, Ibaraki, 567‑0047, Osaka, Japan.
Takasuke FukuharaDepartment of Microbiology and Immunology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, 060-8638, Japan.
Yoichiro FujiokaDepartment of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, 060-8638, Japan. y-fuji@med.hokudai.ac.jp.
Yusuke OhbaDepartment of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, 060-8638, Japan. yohba@med.hokudai.ac.jp.

Funding

Japan Agency for Medical Research and Development JP21gm1610001Japan Society for the Promotion of Science 21H02735Ministry of Education, Culture, Sports, Science and Technology of Japan 19H04823Ministry of Education, Culture, Sports, Science and Technology of Japan 19H05411
6 · The paper itself

Abstract

backgroundInfluenza A viruses (IAVs) initially infect a few host cells before spreading to neighboring cells. However, the molecular mechanisms underlying this dissemination remain unclear. We have previously demonstrated that intracellular Ca

methodsMadin-Darby canine kidney (MDCK) cells stably expressing a Ca

resultsIAV infection upregulated the frequency of intercellular calcium wave propagations (iCWPs), facilitating viral spread. ADP released from initially infected cells mediated iCWPs via the P2Y

conclusionsIntercellular calcium signaling plays a crucial role in the early expansion and establishment of IAV infection, presenting a potential target for IAV prophylaxis.

Indexed as

Calcium SignalingInfluenza A virusAdenosine DiphosphateAnimalsCalciumDogsHumansMadin Darby Canine Kidney CellsReceptors, Purinergic P2Y1Viral Matrix ProteinsAdenosine DiphosphateCalciumReceptors, Purinergic P2Y1Viral Matrix ProteinsCalcium imagingInfluenza A virusIntercellular calcium wave propagationP2Y1 antagonist

Identifiers

PMID40753252
PMCPMC12317542

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.