ArticleEuropean journal of medical research2025
A comparative analysis of postprocedural troponin levels and the impact of renal impairment in patients undergoing pulmonary vein isolation: pulsed field ablation vs. radiofrequency ablation.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pulsed field ablation for the interventional treatment of atrial fibrillation: a scientific statement of the European Heart Rhythm Association of the European Society of Cardiology, the Heart Rhythm Society, the Asia Pacific Heart Rhythm Society, the Latin American Heart Rhythm Society, and the Canadian Heart Rhythm Society.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Guideline
- Pulsed Field Ablation Is Associated With Fewer Post-Procedural Pericardial Inflammatory Symptoms Compared With Radiofrequency Ablation.Journal of cardiovascular electrophysiology · 2026Observational
- Physiological Tissue Response to Pulsed-Field Ablation for Atrial Fibrillation: Insights from Biomarker Kinetics.Physiological research · 2026Article
- PulseSelect vs FARAPULSE pulsed field ablation: Comparative analysis of myocardial, neural-injury and hemolysis biomarkers and short-term outcomes.International journal of cardiology. Heart & vasculature · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulsed field ablation (PFA) has emerged as a novel nonthermal modality for pulmonary vein isolation (PVI) in atrial fibrillation (AF). While it offers distinct advantages over traditional radiofrequency ablation (RFA), including a favorable safety profile, its impact on myocardial injury, as reflected by biomarker plasma concentrations, remains underexplored.
objectivesThis study aimed to compare postprocedural high-sensitivity troponin-T (hs-TnT) and creatine kinase (CK) levels in patients undergoing PVI with PFA versus RFA and to identify independent predictors of myocardial injury.
methodsWe analyzed 94 patients (48 PFA, 46 RFA) undergoing PVI for paroxysmal or persistent AF. Biomarkers (hs-TnT and CK) were measured preprocedure and 24 h postprocedure. Baseline clinical and procedural characteristics were evaluated for comparability. Statistical analyses included linear regression with permutation feature importance to identify predictors of postprocedural troponin levels.
resultsPatients undergoing PFA exhibited significantly higher median hs-TnT levels at 24 h postprocedure compared to those treated with RFA (1071.0 ng/L [IQR: 861.0-1316.5] vs. 602.5 ng/L [IQR: 504.0-795.5]; p < 0.001). Similarly, CK levels were markedly higher in the PFA group (286.0 U/L [IQR: 215.0-356.5] vs. 122.5 U/L [IQR: 90.5-190.5]; p < 0.001). Baseline levels of both biomarkers were comparable between groups. Linear regression identified PFA as the most significant determinant of troponin plasma concentration, followed by preprocedural GFR, with reduced GFR correlating with greater troponin elevation.
conclusionsPFA is associated with higher myocardial biomarker plasma concentration compared to RFA, suggesting greater myocardial injury. Reduced GFR amplifies this effect, underscoring the importance of careful patient selection and procedural planning, particularly in patients with renal impairment. While PFA shows promise as a safe and effective ablation strategy, further research is needed to assess its long-term clinical implications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.