Evidence map›Paper›PMID 40753239›Full record

Trial reportAntimicrobial resistance and infection control2025

Rapid and actionable nasal-swab screening supports antimicrobial stewardship in patients with pneumonia: a prospective study.

Siyao Chen, Yuanyuan Xiao, Caixia Tan, Juan Zhou, Ting Liu, Sisi Zhang, Yiran Hu, Yang Liu, Ming Zheng, Letao Chen and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Antimicrobial resistance and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin: A Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Siyao ChenDepartment of Infection Control Center, Xiangya Hospital Central South University, Changsha, Hunan, China.
Yuanyuan XiaoDepartment of Infection Control Center, Xiangya Hospital Central South University, Changsha, Hunan, China.
Caixia TanDepartment of Infection Control Center, Xiangya Hospital Central South University, Changsha, Hunan, China.
Juan ZhouDepartment of Infection Control Center, Xiangya Hospital Central South University, Changsha, Hunan, China.
Ting LiuDepartment of Infection Control Center, Xiangya Hospital Central South University, Changsha, Hunan, China.
Sisi ZhangDepartment of Infection Control Center, Xiangya Hospital Central South University, Changsha, Hunan, China.
Yiran HuDepartment of Infection Control Center, Xiangya Hospital Central South University, Changsha, Hunan, China.
Yang LiuDepartment of Infection Control Center, Xiangya Hospital Central South University, Changsha, Hunan, China.
Ming ZhengDepartment of Infection Control Center, Xiangya Hospital Central South University, Changsha, Hunan, China.
Letao ChenDepartment of Infection Control Center, Xiangya Hospital Central South University, Changsha, Hunan, China.
Xinghui GaoDepartment of Medical Affairs, Danaher Corporation/Cepheid (China), Shanghai, China.
Yi-Wei TangDepartment of Medical Affairs, Danaher Corporation/Cepheid (China), Shanghai, China.
Fred C TenoverCollege of Arts and Sciences, University of Dayton, Dayton, OH, 45469, USA.
Anhua WuDepartment of Infection Control Center, Xiangya Hospital Central South University, Changsha, Hunan, China. xywuanhua@csu.edu.cn.
Chunhui LiDepartment of Infection Control Center, Xiangya Hospital Central South University, Changsha, Hunan, China. lichunhui@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMethicillin-resistant Staphylococcus aureus (MRSA) nasal screening by polymerase chain reaction (PCR) is a rapid diagnostic tool with a high negative predictive value for pneumonia caused by MRSA. MRSA remains an important emerging pathogen in China and at present, there is little published data on the effect of rapid MRSA test results on antibiotic utilization for pneumonia.

methodsA total of 300 inpatients who met the criteria of pneumonia in a tertiary general hospital were randomly assigned to a notification group (NG, n = 150) or a control group (CG, n = 150). Nasal swabs were collected and tested with the Xpert SA Nasal Complete Test (Cepheid, Sunnyvale, CA) to determine MRSA colonization status. Attending clinicians were immediately informed of test results for patients in NG while results were not released to an attending physician in CG. Subsequently, relevant medical records were collected and analyzed.

resultsPatients in the NG received a shorter duration of antimicrobial therapy compared to the CG (5.66 vs. 7.87 days, P < 0.001). Fewer renal injuries (1.33% vs. 8%; P = 0.015), and lower costs of antimicrobial agents ($621.78 vs. $881.70; P = 0.013) were observed in NG patients compared to those in the CG. Further, this intervention did not increase the in-hospital mortality (12.67% vs. 16.67%, P = 0.327).

conclusionsRapid and actionable MRSA PCR screening using nasal swabs helped reduce unnecessary anti-MRSA treatment. Early management of antimicrobials not only reduced the duration of anti-MRSA drug exposure but also antimicrobial-related adverse events.

Indexed as

Anti-Bacterial AgentsAntimicrobial StewardshipMethicillin-Resistant Staphylococcus aureusAdultAgedAged, 80 and overChinaFemaleHumansMaleMiddle AgedPolymerase Chain ReactionProspective StudiesAnti-Bacterial AgentsAntibioticsAntimicrobial stewardshipMethicillin-resistant Staphylococcus aureusNasal swabPolymerase chain reaction (PCR)

Identifiers

PMID40753239
PMCPMC12318421

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.