ArticleBMC genomics2025
Genome-wide association study of blood vitamin D metabolites and bone remodelling markers in pigs.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundBone integrity is crucial for farm animals, particularly pigs, as it has direct impact on animal health and welfare as well as for a sustainable livestock farming. Blood serum provides valuable insight into bone metabolism and turnover by assessing key indicators of mineral utilization and bone development, such as serum calcidiol (vitamin D
resultsGenomic heritability estimates for these phenotypes showed moderate to low heritability with serum calcidiol (0.14), calcitriol (0.12), ß-CTX (0.15), and CICP (0.12). A total of 17 genomic regions on different chromosomes were identified that contain single-nucleotide polymorphisms significantly associated with these four phenotypes. The integration of positional and functional aspects revealed a total of 23 candidate genes with the highest relevance of PTH, GC, ALB for serum calcidiol, PDPN for serum calcitriol and BTG1, FASN, FOXK2 for serum ß-CTX, and RETSAT, ATOH8, FGF11, ALOX15 for serum CICP.
conclusionThe results emphasize the potential for developing innovative breeding criteria that specifically target bone health in pigs. Hence, mineral utilization efficiency might be indirectly improved which remains to be empirically demonstrated through further research.
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