ArticleBMC cardiovascular disorders2025
Percutaneous endocardial septal radiofrequency ablation in patients with hypertrophic obstructive cardiomyopathy.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Impact of Anterior Mitral Leaflet Length on the Efficacy of Intracardiac Echocardiography-Guided Endocardial Septal Ablation for HOCM.Journal of cardiovascular development and disease · 2026Article
- Bipolar Percutaneous Endocardial Septal Radiofrequency Ablation (Bi-PESA): First-in-Human Application for Hypertrophic Obstructive Cardiomyopathy.JACC. Case reports · 2026Article
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Authors and funding
12 authors.
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Abstract
objectivePercutaneous endocardial septal radiofrequency ablation (PESA) shows promise as a treatment for hypertrophic obstructive cardiomyopathy (HOCM). We aimed to explore the efficacy and safety of PESA require further study during a long-term follow-up.
methodsWe enrolled 25 patients HOCM who underwent PESA. The combination of a three-dimensional electrophysiological mapping system and intracardiac echocardiography (ICE) was employed to guide PESA. The patients were followed for 37 months (25-47.5 months), with transthoracic echocardiography performed 22 months (8-29 months) after the procedure.
resultsThe mean age of patients was 55.3 ± 13.5 years (range: 23 to 79), and 11 (44%) of them were female. PESA led to a significant reduction in the left ventricular outflow tract gradient (LVOTG) from 79.0 ± 37.6 mmHg to 55.6 ± 34.8 mmHg (p = 0.002), as well as syncope episodes (60% vs. 19%, p = 0.0039) in patients with HOCM. The New York Heart Association (NYHA) functional class of the patients was improved from 2.14 ± 0.57 to 1.76 ± 0.54 (p = 0.002). In 10 patients undergoing cardiovascular magnetic resonance imaging (CMRI) both before PESA and at a follow-up of 3-6 months, the maximum left ventricular outflow tract velocity was ameliorated from 232.6 ± 56.8 m/s to 159.4 ± 46.9 m/s (p = 0.024). Besides, the minimum systolic diameter of left ventricular outflow tract was increased from 3.84 ± 2.6 mm to 6.3 ± 2.3 mm (p = 0.0006). There were no instances of cardiac tamponade, lethal arrhythmia, or death. Four patients underwent surgical septal myectomy during the follow-up.
conclusionsPESA could attenuate LVOT obstruction and improve heart function in patients with HOCM during a long-term follow-up. PESA may be an effective and safe treatment for HOCM.
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