Evidence map›Paper›PMID 40753176›Full record

ArticleNature communications2025

Voltage sensor conformations induced by LQTS-associated mutations in hERG potassium channels.

Aaron N Chan, Co D Quach, Lucas J Handlin, Erin N Lessie, Emad Tajkhorshid, Gucan Dai

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Aaron N ChanTheoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.ORCID http://orcid.org/0000-0003-3000-4275
Co D QuachTheoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.ORCID http://orcid.org/0000-0002-1255-4161
Lucas J HandlinEdward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0009-0008-0960-742X
Erin N LessieEdward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, USA.
Emad TajkhorshidTheoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.ORCID http://orcid.org/0000-0001-8434-1010
Gucan DaiEdward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, USA. gucan.dai@health.slu.edu.ORCID http://orcid.org/0000-0002-4692-4060

Funding

Resource for Macromolecular Modeling and VisualizationR24GM145965 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Emad Tajkhorshid · 2022 to 2026
$6.2M
VOLTAGE-SENSING MECHANISMS OF ION CHANNELS IN DYNAMIC LIPID MEMBRANESR35GM154778 · NIGMS · SAINT LOUIS UNIVERSITY · PI Gucan Dai · 2024 to 2026
$1.1M
ELECTROMECHANICAL COUPLING AND DISEASE MECHANISMS OF MYOCARDIAL CNBD FAMILY CHANNELSR56HL169176 · NHLBI · SAINT LOUIS UNIVERSITY · PI DAI, GUCAN · 2024 to 2024
$620k
National Science Foundation (NSF) 221835National Science Foundation (NSF) MCA06N060NHLBI NIH HHS R56 HL169176NIGMS NIH HHS R35 GM154778U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R56HL169176U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R24GM145965U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM154778
6 · The paper itself

Abstract

Voltage sensors are essential for electromechanical coupling in hERG K

Indexed as

ERG1 Potassium ChannelLong QT SyndromeMutationArginineFluorescence Resonance Energy TransferHEK293 CellsHumansIon Channel GatingMembrane PotentialsMolecular Dynamics SimulationProtein ConformationArginineERG1 Potassium ChannelKCNH2 protein, human

Identifiers

PMID40753176
PMCPMC12318091

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.