ArticleNature communications2025
Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics.
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In one paragraph
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Article
- Extracellular vesicles in solid tumors: from tumor ecology to engineered therapeutics.Molecular cancer · 2026Review
- Mechanisms of Pericyte-Mediated Cancer Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The vascular niche: an orchestrator of the spatiotemporal dynamics of distant metastasis.Acta pharmacologica Sinica · 2026Review
- MicroRNA profiles in colostrum and transition milk of non-dairy goats fed with or without resveratrol.Scientific data · 2026Article
- Single-cell profiling uncovers a hypoxia-vascular-immune axis underlying poor immunotherapy response in acral versus cutaneous melanoma.Journal of translational medicine · 2026Article
- Article
- Targeting TCF21-TCF3 heterodimer in tumor-associated pericytes attenuates hematogenous metastasis by restoring pericyte gatekeeper function.Cell reports. Medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Xiaobo Li *State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China.ORCID http://orcid.org/0000-0003-2378-2458
Sishan Yan *State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China.ORCID http://orcid.org/0009-0003-5728-1261
Xiaoyu Wu *State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China.
Qun MiaoState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China.
Dong ZhangDepartment of Medical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Wenfeng MaiDepartment of Medical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Shuai HanDepartment of Gastrointestinal Surgery, General Surgery Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Zhongshun TangDepartment of Gastrointestinal Surgery, General Surgery Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Mingfang YeState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China.
Shuo ZhangSchool of Instrument Science and Engineering, Southeast University, Nanjing, China.
Ji-An WeiKey Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, China.ORCID http://orcid.org/0000-0002-9758-0982
Jinghua PanDepartment of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.ORCID http://orcid.org/0000-0003-3741-3397
Dandan HuangThe Sixth Affiliated Hospital, Sun Yet-sen University, Guangzhou, China.
Shenghui QiuDepartment of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Zhan ZhaoDepartment of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Xiaotong ZhongCollege of Pharmacy, Jinan University, Guangzhou, China.
Maohua HuangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China.
Ming QiState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China.
Junqiu ZhangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China.
Chenran WangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China.ORCID http://orcid.org/0009-0004-8724-8793
Jingwen XieState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China.
Sheng WangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China.
Oscar Junhong LuoDepartment of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou, China. luojh@jnu.edu.cn.ORCID http://orcid.org/0000-0002-1266-3069
Dongmei ZhangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China. dmzhang701@jnu.edu.cn.
Wencai YeState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China. chywc@aliyun.com.ORCID http://orcid.org/0000-0002-2810-1001
Minfeng ChenState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, China. minfengchen@jnu.edu.cn.ORCID http://orcid.org/0000-0003-4200-3261
Funding
China Postdoctoral Science Foundation 2022M711345China Postdoctoral Science Foundation 2022M721356China Postdoctoral Science Foundation 2023M731323China Postdoctoral Science Foundation 2023M741390China Postdoctoral Science Foundation 2023M741391China Postdoctoral Science Foundation BX20230144Guangzhou Science and Technology Program key projects 2025A04J5158Guangzhou Science and Technology Program key projects SL2024A04J00374National Natural Science Foundation of China (National Science Foundation of China) 81973340National Natural Science Foundation of China (National Science Foundation of China) 82003796National Natural Science Foundation of China (National Science Foundation of China) 82204427National Natural Science Foundation of China (National Science Foundation of China) 82204428National Natural Science Foundation of China (National Science Foundation of China) 82273941National Natural Science Foundation of China (National Science Foundation of China) 82304526National Natural Science Foundation of China (National Science Foundation of China) 82404673National Natural Science Foundation of China (National Science Foundation of China) 82473950Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2019A1515110543Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2020A1515010071Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2021A1515110242Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2023B1515120023Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2024A1515013086Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2024B1515020098
Abstract
Hemodynamics are important for survival and extravasation of circulating tumor cells, whereas the effects of hemodynamics on tumor cell intravasation remain mostly unknown. Here, we show that colorectal cancer patients with liver metastasis are characterized by increased diameter and blood flow in the primary tumor compared with non-metastatic patients. A subpopulation of NKX2-3
Indexed as
Colorectal NeoplasmsHemodynamicsLiver NeoplasmsPericytesAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMiceNeoplasm MetastasisRNA, Long NoncodingTranscription FactorsVasodilationRNA, Long NoncodingTranscription Factors
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.