ArticleNature communications2025
Open-source, high performance miniature 2-photon microscopy systems for freely behaving animals.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- MIMAS: An open-source microlens-array miniature microscope for accessible large-field cortical imaging in freely behaving mice.Science advances · 2026Article
- Simultaneous mesoscopic imaging of neural activity and hemodynamics reveals anesthetic modulation of neurovascular responses.Photoacoustics · 2026Article
- MiniFAST: a sensitive and fast miniaturized microscope forNeurophotonics · 2026Article
- Dissecting neuronal circuit function and dysfunction in Alzheimer's disease mouse models: from conventional calcium imaging analysis to machine learning-based approaches.Frontiers in aging neuroscience · 2026Review
- High-speed neural imaging with multiplexed miniaturized two-photon microscopy.Cell reports methods · 2025Article
- High-throughput two-photon volumetric brain imaging in freely moving mice.Nature communications · 2025Article
- Simultaneous two-color imaging with a dual-channel miniscope in freely behaving mice.Science advances · 2025Article
- Opto2P-FCM: A MEMS based miniature two-photon microscope with two-photon patterned optogenetic stimulation.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Here we describe the UCLA 2P Miniscope, an open-source miniature 2-photon microscope capable of recording calcium dynamics from neurons in deep structures and from dendrites over a 445 µm × 380 µm field of view. The system utilizes two on-board silicon-based photon detectors for approximately 4-fold greater light collection compared to an optical fiber bundle-based approach. The microscope can electronically focus within a 150 µm range at a native working distance of 720 µm. To test the 2P Miniscope, we recorded calcium dynamics from place cells in hippocampus, resolved calcium transients from dendrites in retrosplenial cortex and we recorded dentate granule cell activity at a depth of over 620 µm, through an intact hippocampus during open field behavior. The miniature microscope itself and all supporting equipment are open-source and all files needed for building the scope can be accessed through the Golshani Lab GitHub repository.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.