Evidence map›Paper›PMID 40753140›Full record

ArticleScientific reports2025

Development and validation of a gut motility based model for predicting bowel preparation quality.

Hongjiao Wu, Rui Wu, Yunyun Zhang, Xinyi Lu, Wei Zhao, Biyun Xu, Jun Liu, Nina Zhang

Abstract readValidation Study
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hongjiao Wu *Department of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.
Rui Wu *Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Yunyun ZhangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.
Xinyi LuDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Wei ZhaoDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Biyun XuDepartment of Biomedical Statistics, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. drxby@163.com.
Jun LiuDepartment of Gastroenterology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China. sbyy_liujun@163.com.
Nina ZhangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China. zhangnina@njglyy.com.

Funding

fundings for Clinical Trails from the Affiliated Drum Tower Hospital, Medical School of Nanjing University 2023-LCYJ-MS-07Jiangsu Provincial Health Commission Medical Research General Project H2023138Nanjing Medical Key Technology Development Project ZKX22018
6 · The paper itself

Abstract

Inadequate bowel preparation negatively impacts the quality of colonoscopy, potentially resulting in missed lesions and the need for repeat procedures. Although gut motility plays a key role in bowel cleansing, it is often neglected in risk prediction. This study developed and validated a predictive model and simplified scoring system that integrates gut motility parameters to identify individuals at risk of inadequate bowel preparation. A total of 1,165 patients from two hospitals were enrolled, with 815 forming the training set and 350 forming the external validation cohort. The overall rate of inadequate bowel preparation was 9.8%. Multivariate analysis revealed that altered bowel movement frequency, stool consistency based on the Bristol Stool Scale, low polyethylene glycol (PEG) volume, and delayed last bowel movement were significant predictors of poor preparation. These variables were incorporated into a user-friendly scoring system that demonstrated good discriminative ability, with area under the curve values of 0.778 and 0.774 in the training and validation cohorts, respectively. A cutoff score of 3.0 yielded a sensitivity of 75.0%, specificity of 66.9%, and a negative predictive value of 96.3% in external validation. This model provides a practical, motility-informed approach for risk stratification and personalized preparation regimens, offering potential to enhance the effectiveness and efficiency of colonoscopy in diverse clinical settings.

Indexed as

CatharticsColonoscopyGastrointestinal MotilityAdultAgedFemaleHumansMaleMiddle AgedPolyethylene GlycolsCatharticsPolyethylene GlycolsBowel preparationColonoscopyGastrointestinal motilityPredictive learning models

Identifiers

PMID40753140
PMCPMC12318035

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.