Evidence map›Paper›PMID 40753086›Full record

ReviewNPJ Parkinson's disease2025

Position paper: leveraging non-human primate (NHP) specificities to accelerate Parkinson's disease and ageing research.

Erwan Bezard, Rozalyn M Anderson, Romina Aron Badin, Hagai Bergman, Ashley Boehringer, Simon Borgognon, Marina E Emborg, Jeffrey H Kordower, Jia-Yi Li, Anne-Caroline Martel and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Erwan BezardUniv. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France. erwan.bezard@u-bordeaux.fr.
Rozalyn M AndersonDivision of Geriatrics, Department of Medicine, SMPH, University of Wisconsin-Madison, & GRECC, William S Middleton Memorial Veterans Hospital, Madison, WI, USA.
Romina Aron BadinCommissariat à l'Energie Atomique (CEA), Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France.
Hagai BergmanThe Edmond and Lily Safra Center for Brain Science, The Hebrew University, Jerusalem, Israel.
Ashley BoehringerASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, 85281, USA.
Simon BorgognonDepartment of Neurosciences and Movement Sciences, University of Fribourg, Fribourg, Switzerland.
Marina E EmborgPreclinical Parkinson's Research Program, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA.
Jeffrey H KordowerASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, 85281, USA.
Jia-Yi LiLaboratory of Research in Parkinson's Disease and Related Disorders, Health Sciences Institute, China Medical University, Shenyang, China.
Anne-Caroline MartelDepartment of Neurology, Emory National Primate Research Center, Emory University, 954, Gatewood Rd NE, Atlanta, GA, 30329, USA.
Jeanette M MetzgerPreclinical Parkinson's Research Program, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA.
Yoland SmithDepartment of Neurology, Emory National Primate Research Center, Emory University, 954, Gatewood Rd NE, Atlanta, GA, 30329, USA.
Masahiko TakadaDepartment of Neurology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Jun TakahashiDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Ryosuke TakahashiKyoto University Office of Research Acceleration (KURA), Kyoto, 606-8501, Japan.
Benjamin DehayUniv. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France. benjamin.dehay@u-bordeaux.fr.

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Wisconsin Nathan Shock CenterP30AG092586 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson, JOHN M DENU · 2025 to 2026
$3.8M
Molecular Networks in Aging and Caloric Restriction in Rhesus MonkeysR01AG074503 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson · 2022 to 2026
$3.1M
Michael J. Fox Foundation for Parkinson's Research PD AgeNIA NIH HHS P30 AG092586NIA NIH HHS R01 AG074503NIH HHS P51 OD011106
6 · The paper itself

Abstract

The PD-AGE international task force underscores the pivotal role that non-human primate (NHP) models play in advancing our understanding of Parkinson's disease (PD) and ageing. Due to their close genetic, anatomical, and behavioural similarity to humans, NHPs uniquely enable translational research to bridge basic science towards clinical application. They are indispensable for modelling the complex motor and non-motor symptoms of PD, as well as age-related neurodegeneration. This paper outlines the scientific rationale, methodological strengths, and ethical considerations surrounding NHP use in PD research. We highlight the need for standardised models, innovative tools, and long-term collaborative infrastructure to enhance the translational value of NHP studies. We propose a three-phase roadmap to develop a global research consortium to optimise resource use, improve model fidelity, and accelerate therapeutic development for PD and related neurodegenerative disorders.

Identifiers

PMID40753086
PMCPMC12317990

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.