Evidence map›Paper›PMID 40752851›Full record

ArticleUrology2025

Prostate Specific Antigen Testing and Prostate Cancer Diagnosis Rates Among Transgender and Non-Binary Patients: Retrospective Review of a Single-Institution Experience.

Jamie A Michael, Daniel R Greenberg, Mona Ascha, Christopher D Gonzales-Alabastro, Keith Weissman, Emily Chwa, Dylan Felt, Ashley Ross, Lauren Beach, Sumanas W Jordan and 1 more

Abstract read
In one paragraph

Article in Urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jamie A MichaelDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address: jamie.michael@northwestern.edu.
Daniel R GreenbergDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Mona AschaDivision of Plastic and Reconstructive Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL.
Christopher D Gonzales-AlabastroDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Keith WeissmanNorthwestern University Feinberg School of Medicine, Chicago, IL.
Emily ChwaNorthwestern University Feinberg School of Medicine, Chicago, IL.
Dylan FeltDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL.
Ashley RossDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Lauren BeachDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL.
Sumanas W JordanDivision of Plastic and Reconstructive Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL.
Diana K BowenDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL.

Funding

GSH Training GrantT32HD049339 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jennifer S Hirsch · 2006 to 2026
$3.4M
NICHD NIH HHS T32 HD049339
6 · The paper itself

Abstract

objectiveTo characterize prostate-specific antigen (PSA) testing patterns, diagnosis, and treatment and management of prostate cancer in transgender and non-binary patients designated male at birth (TGNB DMAB) at a single tertiary care institution.

methodsWe retrospectively reviewed all patient encounters from March 2019 to February 2021 to identify TGNB DMAB eligible for PSA screening per American Urological Association guidelines. This cohort was analyzed to determine the rate of PSA testing, referral patterns, recommendations, and overall patterns of clinical care.

resultsAmong 216 TGNB DMAB patients identified, 86 (39.8%) had at least 1 PSA during eligible screening years. Median PSA at initial evaluation was 0.16 ng/mL (interquartile range < 0.04-1.14 ng/mL), with significant differences between patients on gender-affirming hormonal therapy or prior orchiectomy (P <.001). In the testing cohort, 45 (52.3%) patients continued PSA testing or further workup after initial evaluation, and 7 (8.1%) patients underwent prostate biopsy. Four (4.5%) were diagnosed with prostate cancer. On logistic regression, Black/African-American race was associated with decreased odds of undergoing any PSA testing (odds ratio 0.51, 95% confidence interval 0.25-1.01, P = .054).

conclusionThe PSA testing rate among TGNB DMAB patients is low compared to published rates among cisgender men. Race may also influence PSA testing patterns in this population; however, further studies are required to validate our result.

Indexed as

Early Detection of CancerProstate-Specific AntigenProstatic NeoplasmsTransgender PersonsAdultAgedHumansMaleMiddle AgedRetrospective StudiesProstate-Specific Antigen

Identifiers

PMID40752851
PMCPMC13097395

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.