Evidence map›Paper›PMID 40752487›Full record

ReviewNeuron2025

Ion channels in respiratory rhythm generation and sensorimotor integration.

Carlos Aparecido da Silva Junior, Maria Cristina D Picardo, Christopher A Del Negro

Abstract readReview
In one paragraph

Review in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. CRISPR/Cas9-mediatedFrontiers in physiology · 2026
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carlos Aparecido da Silva JuniorDepartment of Applied Science, School of Computing, Data Sciences & Physics, William & Mary, Williamsburg, VA 23185, USA; Department of Biology, University of North Carolina at Greensboro, Greensboro, NC 2712, USA.
Maria Cristina D PicardoDepartment of Applied Science, School of Computing, Data Sciences & Physics, William & Mary, Williamsburg, VA 23185, USA.
Christopher A Del NegroDepartment of Applied Science, School of Computing, Data Sciences & Physics, William & Mary, Williamsburg, VA 23185, USA. Electronic address: cadeln@wm.edu.

Funding

Ion Channel Mechanisms of Inspiratory Breathing Movements in MiceR01NS107296 · NINDS · COLLEGE OF WILLIAM AND MARY · PI DEL NEGRO, CHRISTOPHER A. · 2019 to 2022
$1.1M
Molecular characterization of expiratory breathing-related interneurons in mammalsR21NS134005 · NINDS · COLLEGE OF WILLIAM AND MARY · PI CONRADI SMITH, GREGORY DOUGLAS, DEL NEGRO, CHRISTOPHER A. · 2023 to 2023
$410k
Role of TRP Channels in Respiratory Rhythm and BreathingR21NS087257 · NINDS · COLLEGE OF WILLIAM AND MARY · PI DEL NEGRO, CHRISTOPHER A. · 2015 to 2016
$388k
NINDS NIH HHS R01 NS107296NINDS NIH HHS R21 NS087257NINDS NIH HHS R21 NS134005
6 · The paper itself

Abstract

Breathing movements depend on rhythmic neural activity in brainstem nuclei whose constituent neurons are well characterized. Knowing the sites and cells underlying the behavior enables us to identify the roles of individual ion channels. They accomplish three tasks: regulate excitability via the balance of intrinsic currents that govern baseline membrane potential and tonic firing; generate bursts to drive the motor output pattern; and transduce blood-gas levels, lung volume, and air qualities. Here, we explain how sodium and mixed cation channels (sodium leak channel non-selective [NALCN], Na

Indexed as

Brain StemFeedback, SensoryIon ChannelsRespirationAnimalsHumansIon Channelscentral pattern generatoreupneaexpirationinspirationinteroceptionparafacialpostinspirationpre-Bötzinger complexpreBötzinger complexretrotrapezoid nucleus

Identifiers

PMID40752487
PMCPMC12321211

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.