Evidence map›Paper›PMID 40752380›Full record

ArticleJournal of autoimmunity2025

Interaction between haploinsufficiency of PTPN2 and patient microbiome promotes autoimmune arthritis in mice.

Sho Sendo, Allison J Vela, Myungja Ro, Deepan Thiruppathy, Elizabeth L Wilkinson, Zixuan Zhao, Wan-Chen Hsieh, Shen Yang, Roxana Coras, Anne-Sophie Bergot and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autoimmunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Sho SendoDept. of Medicine, University of California San Diego, La Jolla, CA, 92093, United States; Dept. of Rheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan.
Allison J VelaDept. of Medicine, University of California San Diego, La Jolla, CA, 92093, United States; Dept. of Medicine, Kao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, United States.
Myungja RoDept. of Medicine, University of California San Diego, La Jolla, CA, 92093, United States; Dept. of Medicine, Kao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, United States.
Deepan ThiruppathyDept. of Bioengineering, University of California San Diego, La Jolla, CA, 92093, United States.
Elizabeth L WilkinsonDept. of Chemical and Nano Engineering, University of California, La Jolla, San Diego, CA, 92093, United States.
Zixuan ZhaoDept. of Medicine, University of California San Diego, La Jolla, CA, 92093, United States.
Wan-Chen HsiehDept. of Medicine, University of California San Diego, La Jolla, CA, 92093, United States; Institute of Molecular and Cellular Biology, National Tsing-Hua University, Hsinchu, Taiwan.
Shen YangDept. of Medicine, University of California San Diego, La Jolla, CA, 92093, United States; Dept. of Medicine, Kao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, United States.
Roxana CorasDept. of Medicine, University of California San Diego, La Jolla, CA, 92093, United States; Dept. of Medicine, Kao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, United States.
Anne-Sophie BergotFrazer Institute, The University of Queensland, Translational Research Institute (TRI), Woolloongabba, QLD, 4102, Australia.
Monica GumaDept. of Medicine, University of California San Diego, La Jolla, CA, 92093, United States.
Anders NguyenDept. of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, 41346, Sweden; SciLifeLab, University of Gothenburg, 41346, Sweden.
David A McBrideDept. of Chemical and Nano Engineering, University of California, La Jolla, San Diego, CA, 92093, United States.
Suzanne DevkotaDept. of Medicine, Human Microbiome Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, United States.
Ranjeny ThomasFrazer Institute, The University of Queensland, Translational Research Institute (TRI), Woolloongabba, QLD, 4102, Australia.
Nisarg J ShahDept. of Chemical and Nano Engineering, University of California, La Jolla, San Diego, CA, 92093, United States.
Mattias N D SvenssonDept. of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, 41346, Sweden; SciLifeLab, University of Gothenburg, 41346, Sweden.
Karsten ZenglerDept. of Bioengineering, University of California San Diego, La Jolla, CA, 92093, United States; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, 92093, United States; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, United States; Program in Materials Science and Engineering, University of California San Diego, La Jolla, CA, 92093, United States.
Stephanie M StanfordDept. of Medicine, University of California San Diego, La Jolla, CA, 92093, United States.
Nunzio BottiniDept. of Medicine, University of California San Diego, La Jolla, CA, 92093, United States; Dept. of Medicine, Kao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, United States. Electronic address: nunzio.bottini@cshs.org.

Funding

Role of PTPN2 in rheumatoid arthritisR01AI148073 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOTTINI, NUNZIO · 2019 to 2023
$2.7M
NIAID NIH HHS R01 AI148073
6 · The paper itself

Abstract

Gut dysbiosis is observed in patients with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), however, how it promotes disease in interaction with other environmental and genetic risk factors remains unclear. Here we assessed interactions between gut dysbiosis and RA/JIA-associated loss of function haplotypes of the RA/JIA-associated PTPN2 gene by inducing mannan-induced arthritis in germ-free PTPN2

Indexed as

Arthritis, ExperimentalArthritis, JuvenileArthritis, RheumatoidDysbiosisGastrointestinal MicrobiomeHaploinsufficiencyProtein Tyrosine Phosphatase, Non-Receptor Type 2AnimalsDisease Models, AnimalFecal Microbiota TransplantationFemaleHumansMaleMiceProtein Tyrosine Phosphatase, Non-Receptor Type 2PTPN2 protein, humanPtpn2 protein, mouse

Identifiers

PMID40752380
PMCPMC12974606

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.