Evidence map›Paper›PMID 40751978›Full record

ArticleOptics letters2025

Phase-sensitive dynamic micro-optical coherence tomography for high-speed intracellular motion imaging.

Hinnerk Schulz-Hildebrandt, Joseph A Gardecki, Tiffany Miller, Maria Avila-Wallace, Erica Villareyna-Lopez, Guillermo Tearney

Abstract read
In one paragraph

Article in Optics letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hinnerk Schulz-Hildebrandt
Joseph A Gardecki
Tiffany Miller
Maria Avila-Wallace
Erica Villareyna-Lopez
Guillermo Tearney

Funding

Dynamic µOCT for cellular tissue phenotypingR01CA265742 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JONAS, OLIVER, TEARNEY, GUILLERMO J · 2021 to 2025
$3.0M
NCI NIH HHS R01 CA265742
6 · The paper itself

Abstract

Dynamic optical coherence tomography with micrometer resolution (DµOCT) offers enhanced contrast information by evaluating time-dependent signal fluctuations in images of living tissue. DµOCT's use has been limited to imaging excised fresh tissue specimens or 3D cell cultures due to the long observation times required, typically ranging from 1.35 to 25 seconds. To reduce the time needed to obtain DµOCT images, we developed a phase-based algorithm that analyzes intracellular motion by measuring phase changes between adjacent B-scans. This approach significantly reduces imaging time to as low as 40.5 ms while providing a quantitative measure of intracellular motion.

Indexed as

Intracellular SpaceTomography, Optical CoherenceAlgorithmsAnimalsHumansMotionMovementTime Factors

Identifiers

PMID40751978
PMCPMC12801154

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.