Evidence map›Paper›PMID 40751852›Full record

ArticleJournal of ophthalmic inflammation and infection2025

Unilateral uveitis following adjuvanted Varicella-Zoster subunit vaccine in a patient with previously resolved Varicella Zoster acute retinal necrosis.

A Trinco, F Zicarelli, F Romano, M Oldani, A Riva, A Invernizzi

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In one paragraph

Article in Journal of ophthalmic inflammation and infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A TrincoDepartment of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, Eye Clinic, University of Milan, Via G.B. Grassi, 74, Milan, 20157, Italy.
F ZicarelliDepartment of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, Eye Clinic, University of Milan, Via G.B. Grassi, 74, Milan, 20157, Italy.
F RomanoDepartment of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, Eye Clinic, University of Milan, Via G.B. Grassi, 74, Milan, 20157, Italy.
M OldaniDepartment of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, Eye Clinic, University of Milan, Via G.B. Grassi, 74, Milan, 20157, Italy.
A RivaDepartment of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milan, Italy.
A InvernizziDepartment of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, Eye Clinic, University of Milan, Via G.B. Grassi, 74, Milan, 20157, Italy. alessandro.invernizzi@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report a case of intraocular inflammation following adjuvanted recombinant Varicella-Zoster subunit vaccine (RZV) in a patient with previously resolved VZV-related acute retinal necrosis (ARN).

methodsSingle case report. Multimodal imaging, including true-color fundus photography, spectral-domain (SD-OCT) and dye-based angiography, was used to evaluate the retinal alterations.

resultsA 73-year-old male, with past history of VZV-related acute retinal necrosis (ARN) developed unilateral cystoid macular edema and diffuse blood-retinal barrier (BRB) breakdown in the affected eye after receiving the second dose of RZV vaccine. A complete resolution of this complication was observed after a short course of systemic corticosteroids.

conclusionOur case suggests a possible pathogen-specific intraocular inflammatory reaction, resembling immune reconstitution uveitis (IRU), following RZV administration in a patient with previously resolved VZV-related ARN. While RZV remains safe, intraocular inflammation should be considered as a possible side effect in patients with previously resolved VZV uveitis.

Identifiers

PMID40751852
PMCPMC12317926

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